Insights into the evolution of mutations in SARS-CoV-2 non-spike proteins

The COVID-19 pandemic has been driven by the emergence of SARS-CoV-2 variants with mutations across all the viral proteins. Although mutations in the spike protein have received significant attention, understanding the prevalence and potential impact of mutations in other viral proteins is essential...

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Bibliographic Details
Published in:Microbial pathogenesis 2023-12, Vol.185, p.106460-106460, Article 106460
Main Authors: Arya, Rimanshee, Tripathi, Preeti, Nayak, Karthik, Ganesh, Janani, Bihani, Subhash C., Ghosh, Biplab, Prashar, Vishal, Kumar, Mukesh
Format: Article
Language:English
Subjects:
COVID-19 infection
evolution
mutation
pathogenesis
Severe acute respiratory syndrome coronavirus 2
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Summary:The COVID-19 pandemic has been driven by the emergence of SARS-CoV-2 variants with mutations across all the viral proteins. Although mutations in the spike protein have received significant attention, understanding the prevalence and potential impact of mutations in other viral proteins is essential for comprehending the evolution of SARS-CoV-2. Here, we conducted a comprehensive analysis of approximately 14 million sequences of SARS-CoV-2 deposited in the GISAID database until December 2022 to identify prevalent mutations in the non-spike proteins at the global and country levels. Additionally, we evaluated the energetics of each mutation to better understand their impact on protein stability. While the consequences of many mutations remain unclear, we discuss potential structural and functional significance of some mutations. Our study highlights the ongoing evolutionary process of SARS-CoV-2 and underscores the importance of understanding changes in non-spike proteins.
ISSN:0882-4010
1096-1208
DOI:10.1016/j.micpath.2023.106460