Stem cells and diabetic retinopathy: From models to treatment

Diabetic retinopathy is a common yet complex microvascular disease, caused as a complication of diabetes mellitus. Associated with hyperglycemia and subsequent metabolic abnormalities, advanced stages of the disease lead to fibrosis, subsequent visual impairment and blindness. Though clinical postmo...

Full description

Saved in:
Bibliographic Details
Published in:Molecular biology reports 2023-05, Vol.50 (5), p.4517-4526
Main Authors: Saha, Bihan, Roy, Akshita, Beltramo, Elena, Sahoo, Om Saswat
Format: Article
Language:English
Subjects:
Angiogenesis
Animal Anatomy
Animal Biochemistry
Animal models
Animals
Apoptosis
Biomedical and Life Sciences
blindness
Cell culture
Cell therapy
Diabetes
Diabetes mellitus
Diabetes Mellitus - metabolism
Diabetic retinopathy
Diabetic Retinopathy - metabolism
Diabetic Retinopathy - therapy
Fibrosis
Histology
Hyperglycemia
Life Sciences
Mesenchymal stem cells
Microvasculature
Morphology
neurons
Pathophysiology
Pericytes
Pericytes - metabolism
prognosis
Retina
Retina - metabolism
Retinopathy
Review
Stem Cell Transplantation - adverse effects
Stem cells
therapeutics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Diabetic retinopathy is a common yet complex microvascular disease, caused as a complication of diabetes mellitus. Associated with hyperglycemia and subsequent metabolic abnormalities, advanced stages of the disease lead to fibrosis, subsequent visual impairment and blindness. Though clinical postmortems, animal and cell models provide information about the progression and prognosis of diabetic retinopathy, its underlying pathophysiology still needs a better understanding. In addition to it, the loss of pericytes, immature retinal angiogenesis and neuronal apoptosis portray the disease treatment to be challenging. Indulged with cell loss of both vascular and neuronal type cells, novel therapies like cell replacement strategies by various types of stem cells have been sightseen as a possible treatment of the disease. This review provides insight into the pathophysiology of diabetic retinopathy, current models used in modelling the disease, as well as the varied aspects of stem cells in generating three-dimensional retinal models. Further outlook on stem cell therapy and the future directions of stem cell treatment in diabetic retinopathy have also been contemplated.
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-023-08337-0