Two new phenylbutenoids from the rhizomes of cassumunar ginger and their α-glucosidase inhibitory activity

An extract from the rhizomes of Cassumunar ginger (Zingiber purpureum Roscoe). was found to have significant α-glucosidase inhibitory activity with an IC 50 value of 6.3 µg/mL. Two new phenylbutenoids, cassudimin A (1) and cassumunol N (2), and seven known compounds (3-9) were isolated. Their struct...

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Bibliographic Details
Published in:Natural product research 2024-05, Vol.38 (9), p.1545-1552
Main Authors: Le, Tho Huu, Nguyen, Ngan Kim Thi, Nguyen, Mai Thanh Thi, Nguyen, Nhan Trung
Format: Article
Language:English
Subjects:
Acarbose
Aquatic plants
diphenylbutenoid
Ginger
Glucosidase
Rhizomes
Zingiber montanum
Zingiber purpureum
α-Glucosidase
α-glucosidase inhibitory
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Summary:An extract from the rhizomes of Cassumunar ginger (Zingiber purpureum Roscoe). was found to have significant α-glucosidase inhibitory activity with an IC 50 value of 6.3 µg/mL. Two new phenylbutenoids, cassudimin A (1) and cassumunol N (2), and seven known compounds (3-9) were isolated. Their structures and relative configurations of two new compounds were elucidated based on spectra interpretation. Compounds 1-3, 6-9 showed more potent α-glucosidase inhibitory activity than a positive control, acarbose (IC 50 = 168.0 µM). Dehydrozingerone (6) exhibited the most potent α-glucosidase inhibition with an IC 50 value of 8.3 μM. Compounds 7 and 9 were found in Z. purpureum rhizomes for the first time.
ISSN:1478-6419
1478-6427
1478-6427
DOI:10.1080/14786419.2022.2157826