The Power of Psychobiotics in Depression: A Modern Approach through the Microbiota-Gut-Brain Axis: A Literature Review

The microbiota-gut-brain (MGB) axis is a complex communication network linking the gut, microbiota, and brain, influencing various aspects of health and disease. Dysbiosis, a disturbance in the gut microbiome equilibrium, can significantly impact the MGB axis, leading to alterations in microbial com...

Full description

Saved in:
Bibliographic Details
Published in:Nutrients 2024-04, Vol.16 (7), p.1054
Main Authors: Dziedzic, Angela, Maciak, Karina, Bliźniewska-Kowalska, Katarzyna, Gałecka, Małgorzata, Kobierecka, Weronika, Saluk, Joanna
Format: Article
Language:English
Subjects:
Antidepressants
Anxiety
Bacteria
Brain
Brain-derived neurotrophic factor
Brain-Gut Axis
Corticosteroids
cortisol
Depression - therapy
Dysbiosis
Enzymes
Fatty acids
Gastrointestinal Microbiome
Gene expression
Health aspects
Homeostasis
Humans
Immune response
Influence
intestinal microorganisms
intestines
Mental depression
Mental disorders
mental health
Metabolism
Metabolites
microbiome
Microbiota
Microbiota (Symbiotic organisms)
Motility
Neurological disorders
Peptides
Probiotics
Serotonin
therapeutics
Well being
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The microbiota-gut-brain (MGB) axis is a complex communication network linking the gut, microbiota, and brain, influencing various aspects of health and disease. Dysbiosis, a disturbance in the gut microbiome equilibrium, can significantly impact the MGB axis, leading to alterations in microbial composition and function. Emerging evidence highlights the connection between microbiota alterations and neurological and psychiatric disorders, including depression. This review explores the potential of psychobiotics in managing depressive disorders, emphasizing their role in restoring microbial balance and influencing the MGB axis. Psychobiotics exhibit positive effects on the intestinal barrier, immune response, cortisol levels, and the hypothalamic-pituitary-adrenal (HPA) axis. Studies suggest that probiotics may serve as an adjunct therapy for depression, especially in treatment-resistant cases. This review discusses key findings from studies on psychobiotics interventions, emphasizing their impact on the gut-brain axis and mental health. The increasing acceptance of the expanded concept of the MGB axis underscores the importance of microorganisms in mental well-being. As our understanding of the microbiome's role in health and disease grows, probiotics emerge as promising agents for addressing mental health issues, providing new avenues for therapeutic interventions in depressive disorders.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu16071054