Salviamilthone A-O, diterpenoid quinones from Salvia miltiorrhiza

Fifteen undescribed diterpenoid quinones salviamilthone A-O (1–15), together with three known diterpenoid quinones (16–18), were isolated from the roots of Salvia miltiorrhiza Bunge. Their structures were elucidated using 1D and 2D NMR data, while the relative and absolute configurations were confir...

Full description

Saved in:
Bibliographic Details
Published in:Phytochemistry (Oxford) 2023-11, Vol.215, p.113840-113840, Article 113840
Main Authors: Ren, Ying-Jie, Cao, Yan-Gang, Zeng, Meng-Nan, Zhang, Qin-Qin, Liu, Yan-Ling, He, Chen, Chen, Xu, Fan, Xi-Ling, Li, Xiang-Da, Zheng, Xiao-Ke, Feng, Wei-Sheng
Format: Article
Language:English
Subjects:
BEAS-2B cells
cell viability
Diterpenoid quinones
diterpenoids
Labiatae
LPS
lungs
plant biochemistry
quinones
Salvia miltiorrhiza
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Fifteen undescribed diterpenoid quinones salviamilthone A-O (1–15), together with three known diterpenoid quinones (16–18), were isolated from the roots of Salvia miltiorrhiza Bunge. Their structures were elucidated using 1D and 2D NMR data, while the relative and absolute configurations were confirmed by NOESY correlations and comparison between experimental and calculated ECD spectra. In the evaluation of bioactivities, salviamilthone J (10), salviamone (18) (10 μM) significantly increased cell viability and decreased the expression of IL-1β in lipopolysaccharide-induced BEAS-2B cells. These data provide the molecular justification for the usage of Salvia miltiorrhiza in treating acute lung injury. Fifteen undescribed diterpenoid quinones were isolated from the dried roots of S. miltiorrhiza. [Display omitted] •Fifteen undescribed diterpenoid quinones were isolated from the dried roots of Salvia miltiorrhiza.•Their structures were elucidated by NMR and mass spectrometry.•All the isolated compounds were evaluated in vitro for their lung-protective effects.
ISSN:0031-9422
1873-3700
DOI:10.1016/j.phytochem.2023.113840