Vaccination during pregnancy and modulation of IgG response to pertussis vaccines in infants: The impact of different vaccine formulations

The IgG response following infant diphtheria-tetanus-acellular pertussis (DTaP) immunization is influenced by the formulation of the infant and/or the adult vaccine (Tdap) given during pregnancy. DTaP vaccines containing either 3 (DTaP3) or 5 (DTaP5) pertussis antigens are commonly used. By conducti...

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Bibliographic Details
Published in:Vaccine 2024-04, Vol.42 (9), p.2138-2143
Main Authors: Brousseau, Nicholas, Angers-Goulet, Marie-Elen, Bastien, Robin, Ye, Lingyun, Sadarangani, Manish, Halperin, Scott A.
Format: Article
Language:English
Subjects:
adults
Age
Antigens
Babies
Diphtheria
Enzymes
Immunization
Immunoglobulin G
Immunomodulation
Infants
Interference
Mothers
Pertussis
Pertussis toxin
Pregnancy
randomized clinical trials
Secondary analysis
Tetanus
Toxins
Vaccination
Vaccines
Whooping cough
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Summary:The IgG response following infant diphtheria-tetanus-acellular pertussis (DTaP) immunization is influenced by the formulation of the infant and/or the adult vaccine (Tdap) given during pregnancy. DTaP vaccines containing either 3 (DTaP3) or 5 (DTaP5) pertussis antigens are commonly used. By conducting a secondary analysis of a large randomized controlled trial, we compared IgG levels against pertussis vaccine antigens in children of Td- and Tdap5-vaccinated mothers, after stratifying by infant vaccine formulation. After immunization with a primary series of DTaP5, but not DTaP3, IgG GMCs against pertussis antigens were significantly lower in infants of Tdap-immunized mothers compared with infants of Td-vaccinated mothers (pertussis toxin: GMC = 52.3[Tdap5] vs 83.5[Td], p 
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2024.03.015