Vaccination during pregnancy and modulation of IgG response to pertussis vaccines in infants: The impact of different vaccine formulations

The IgG response following infant diphtheria-tetanus-acellular pertussis (DTaP) immunization is influenced by the formulation of the infant and/or the adult vaccine (Tdap) given during pregnancy. DTaP vaccines containing either 3 (DTaP3) or 5 (DTaP5) pertussis antigens are commonly used. By conducti...

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Published in:Vaccine 2024-04, Vol.42 (9), p.2138-2143
Main Authors: Brousseau, Nicholas, Angers-Goulet, Marie-Elen, Bastien, Robin, Ye, Lingyun, Sadarangani, Manish, Halperin, Scott A.
Format: Article
Language:English
Subjects:
adults
Age
Antigens
Babies
Diphtheria
Enzymes
Immunization
Immunoglobulin G
Immunomodulation
Infants
Interference
Mothers
Pertussis
Pertussis toxin
Pregnancy
randomized clinical trials
Secondary analysis
Tetanus
Toxins
Vaccination
Vaccines
Whooping cough
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container_title Vaccine
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creator Brousseau, Nicholas
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description The IgG response following infant diphtheria-tetanus-acellular pertussis (DTaP) immunization is influenced by the formulation of the infant and/or the adult vaccine (Tdap) given during pregnancy. DTaP vaccines containing either 3 (DTaP3) or 5 (DTaP5) pertussis antigens are commonly used. By conducting a secondary analysis of a large randomized controlled trial, we compared IgG levels against pertussis vaccine antigens in children of Td- and Tdap5-vaccinated mothers, after stratifying by infant vaccine formulation. After immunization with a primary series of DTaP5, but not DTaP3, IgG GMCs against pertussis antigens were significantly lower in infants of Tdap-immunized mothers compared with infants of Td-vaccinated mothers (pertussis toxin: GMC = 52.3[Tdap5] vs 83.5[Td], p 
doi_str_mv 10.1016/j.vaccine.2024.03.015
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DTaP vaccines containing either 3 (DTaP3) or 5 (DTaP5) pertussis antigens are commonly used. By conducting a secondary analysis of a large randomized controlled trial, we compared IgG levels against pertussis vaccine antigens in children of Td- and Tdap5-vaccinated mothers, after stratifying by infant vaccine formulation. After immunization with a primary series of DTaP5, but not DTaP3, IgG GMCs against pertussis antigens were significantly lower in infants of Tdap-immunized mothers compared with infants of Td-vaccinated mothers (pertussis toxin: GMC = 52.3[Tdap5] vs 83.5[Td], p &lt; 0.001). Before and after the DTaP booster dose, IgG GMCs were similar in infants of Tdap- and Td-immunized mothers specifically when infants received the DTaP3 vaccine. 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source ScienceDirect Freedom Collection 2022-2024
subjects adults
Age
Antigens
Babies
Diphtheria
Enzymes
Immunization
Immunoglobulin G
Immunomodulation
Infants
Interference
Mothers
Pertussis
Pertussis toxin
Pregnancy
randomized clinical trials
Secondary analysis
Tetanus
Toxins
Vaccination
Vaccines
Whooping cough
title Vaccination during pregnancy and modulation of IgG response to pertussis vaccines in infants: The impact of different vaccine formulations
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