Biofabrication of Mg-doped ZnO nanostructures for hemolysis and antibacterial properties

• Published in: Bioprocess and biosystems engineering 2023-12, Vol.46 (12), p.1817-1824
• Main Authors: Al-Odayni, Abdel-Basit, Alnehia, Adnan, Al-Sharabi, Annas, Al-Hammadi, A. H., Saeed, Waseem Sharaf, Abduh, Naaser A. Y.
• Format: Article
• Language: English
• Subjects: Antibacterial activity; antibacterial properties; Bacteria; biofabrication; bioprocessing; Biotechnology; Chemistry; Chemistry and Materials Science; Crystallites; Crystals; Diameters; E coli; Electron microscopes; Elongated structure; Environmental Engineering/Biotechnology; Escherichia coli; Food Science; Hemolysis; Hexagonal phase; Industrial and Production Engineering; Industrial Chemistry/Chemical Engineering; Leaves; Magnesium; medicine; Metal oxides; Morphology; Nanocomposites; Nanoparticles; Nitrates; Orthopedics; Plectranthus barbatus; Research Paper; Scanning electron microscopy; Structural integrity; Synthesis; X-ray diffraction; Zinc oxide; Zinc oxides
• ISSN: 1615-7591; 1615-7605
• DOI: 10.1007/s00449-023-02937-7

The aim of this work was to synthesize 0.02 and 0.06 Mg-doped ZnO nanoparticles (NPs) using the aqueous extract of Plectranthus barbatus leaf. The structural integrity of the hexagonal phase was emphasized by X-ray diffraction analysis. The average crystallite size ( D ) of 0.02 and 0.06 Mg-doped ZnO NPs was found to be 23.83 and 26.95 nm, respectively. The scanning electron microscope images revealed a surface morphology of irregular nano-shapes of about 83 nm diameter with an elongated one-dimensional structure. The hemolysis activity demonstrated the safe nature of the synthesized materials at low doses. Antibacterial activity against S. aureus and E. coli , which assessed using the disc diffusion method, indicated that the prepared NPs could inhibit S. aureus but not E. coli . These findings suggest that the synthesized NPs could be explored for potential applications in biotechnology and medicine.