Chitosan oligosaccharide-loaded bacterial cellulose membrane for hemostatic dressing

Hemorrhagic shock is the leading cause of preventable deaths in traumatic accidents, emphasizing the significance of hemostasis-promoting materials and their incorporation into a pre-hospital medical response system. Bacterial cellulose has drawn much attention in tissue engineering due to its versa...

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Bibliographic Details
Published in:Cellulose (London) 2023-12, Vol.30 (18), p.11649-11664
Main Authors: Nguyen, Nghi Thi-Phuong, Nguyen, Huy Hoang, Doan, Hoan Ngoc, Pham, Kien Trung, Van Nguyen, Khiem, Vu, Binh Thanh, Luong, Tin Dai, Phan, Bach Thang, Ta, Hanh Kieu Thi, Tran, Ngoc Quyen, Tang, Tuan-Ngan, Dang, Nhi Ngoc-Thao, Nguyen, Thi-Hiep
Format: Article
Language:English
Subjects:
Biocompatibility
Bioorganic Chemistry
Blood
Cellulose
Ceramics
Chemistry
Chemistry and Materials Science
Chitosan
Clotting
Composites
Glass
Hemorrhage
hemostasis
Hemostatics
In vivo methods and tests
Membranes
Natural Materials
Oligosaccharides
Organic Chemistry
Original Research
Physical Chemistry
Physical properties
Polymer Sciences
strength (mechanics)
Sustainable Development
Tissue engineering
viability
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Summary:Hemorrhagic shock is the leading cause of preventable deaths in traumatic accidents, emphasizing the significance of hemostasis-promoting materials and their incorporation into a pre-hospital medical response system. Bacterial cellulose has drawn much attention in tissue engineering due to its versatility and biocompatibility. In this study, a hemostatic dressing was composed of bacterial cellulose (BC) and chitosan oligosaccharide (COS), which is a well-known biological agent. The influence of chitosan oligosaccharide on the morphology, chemical, and physical properties of the fabricated cellulose membranes was evaluated. Additionally, the hemostatic performance of BC-COS membranes was investigated through in vitro and in vivo experiments. The results show that the addition of COS led to a lower mechanical strength while increasing the hemostatic properties of the BC membrane. The BC membrane modified with 2 w/v% COS solution (BC-COS2) demonstrated excellent hemostasis promotion through whole blood assays and mice hemorrhage model. The blood clotting index and blood clotting time of the BC-COS2 sample reached 86.25% and 190 s, respectively. Furthermore, in the in vivo experiments, the group treated using BC-COS2 also presented much lower bleeding stop time and blood loss compared to the untreated group. The results reveal the viability of the cellulosic material as a potential hemostatic dressing.
ISSN:0969-0239
1572-882X
DOI:10.1007/s10570-023-05574-1