Polymorphism and association study of lactoferrin (LF) gene with milk yield, milk composition, and somatic cell count in Beetal goats

The sequence analysis of PCR product exhibited four novel SNPs in the promoter region of the LF gene at loci g.98T>C, g.143T>A, g.189AC>A, and g.346A>G. Each SNP yielded three genotypes; the genotypes TT (SNP1), AA (SNP3), and GG (SNP4) decreased SCC and increase milk quality traits such...

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Bibliographic Details
Published in:Tropical animal health and production 2023-12, Vol.55 (6), p.415-415, Article 415
Main Authors: Kinkpe, Lionel, Khan, Rajwali, Suhail, Syed Muhammad, Ahmad, Ijaz, Khan, Farhan Anwar, Ayari-Akkari, Amel, Siddiqui, Sazada
Format: Article
Language:English
Subjects:
Animals
Beetal
Binding sites
Biomedical and Life Sciences
Breeding of animals
Cell Count - veterinary
Gene polymorphism
genes
Genetic markers
Genotype
Genotype & phenotype
Genotypes
Goats - genetics
Goats - metabolism
Lactoferrin
Lactoferrin - genetics
Lactose
Life Sciences
loci
Marker-assisted selection
Milk
Milk - chemistry
Milk production
milk yield
Polymorphism
Polymorphism, Single Nucleotide
promoter regions
Proteins
Regular Articles
Sequence analysis
Single-nucleotide polymorphism
somatic cell count
Veterinary Medicine/Veterinary Science
Zoology
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Summary:The sequence analysis of PCR product exhibited four novel SNPs in the promoter region of the LF gene at loci g.98T>C, g.143T>A, g.189AC>A, and g.346A>G. Each SNP yielded three genotypes; the genotypes TT (SNP1), AA (SNP3), and GG (SNP4) decreased SCC and increase milk quality traits such as density, protein, and milk yield ( P < 0.01). The genotype CC (SNP2) and CA (SNP4) significantly ( P < 0.01) decreased the milk quality parameters, while genotypes TC (SNP2) and GG (SNP4) showed significantly ( P < 0.01) less SCC and increase lactose % in milk. Furthermore, screening of the LF promoter sequence explored the gain of four TF binding sites at locus g.98T˃C and three TF binding sites at g.346A˃G. However, the loss of four and two TF binding sites was seen at locus g.143T˃A and g.189C˃A, respectively. We can conclude from the present study that the GG, TT, and AA genotype might be utilized as genetic markers in marker-assisted selection for the breed improvement program of Beetal goats.
ISSN:0049-4747
1573-7438
DOI:10.1007/s11250-023-03834-7