Unveiling the etiological impact of GST-M1, GST-T1, and P53 genotypic variations on brain carcinogenesis

• Published in: Molecular biology reports 2024-12, Vol.51 (1), p.45-45, Article 45
• Main Authors: Dirican, Onur, Kaygın, Pınar, Oğuztüzün, Serpil, Husseini, Abbas Ali, Sarıaltın, Sezen Yılmaz, Yılmaz, Can, Ünlü, Nihan, İzci, Yusuf
• Format: Article
• Language: English
• Subjects: Alleles; Animal Anatomy; Animal Biochemistry; Biomedical and Life Sciences; brain; Brain cancer; brain neoplasms; Brain tumors; Carcinogenesis; Carcinogens; Epidemiology; etiology; exons; Gene frequency; Gene polymorphism; Gene pool; genotype; Genotype & phenotype; Glutathione; Glutathione transferase; Histology; hospitals; Life Sciences; metabolism; Morphology; Neurosurgery; null alleles; Original Article; p53 Protein; Patients; Polymorphism; risk; Sequence analysis; Single-nucleotide polymorphism; Tumors; xenobiotics
• ISSN: 0301-4851; 1573-4978
• DOI: 10.1007/s11033-023-08985-2

Background Functional variants of glutathione-S-transferase (GST)-M1, GST-T1, p53 might modulate brain cancer risk by altering the rate of metabolism and clearance of carcinogens from the brain tissue. In this study, the role of GST-M1, GST-T1, p53 polymorphisms on brain tumor was investigated. Methods and results Brain tumor tissues of 143 patients were obtained from the Gulhane Training and Research Hospital, Department of Neurosurgery between 2019 and 2020. In the xenobiotic mechanism, the null allele frequency in the GST-T1, GST-M1 gene regions of Phase II enzymes by qPCR method were investigated. Single nucleotide polymorphism encoding Arg/Pro conversion in the p53 gene region was analyzed in 120 cases by sequence analysis method. The data were analyzed statistically with patient’s demographic and clinical data. GST-M1, GST-T1, p53 genotypes of the patient group were determined. The most frequent genotype was null genotype (0/0) for GST-M1 (χ 2  = 39.756, p