Albumin-coated green-synthesized zinc oxide nanoflowers inhibit skin melanoma cells growth via intra-cellular oxidative stress

Zinc oxide (ZnO) has attracted a substantial interest in cancer research owing to their promising utility in cancer imaging and therapy. This study aimed to synthesized ZnO nanoflowers coated with albumin to actively target and the inhibit skin melanoma cells. We synthesized bovine serum albumin (BS...

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Bibliographic Details
Published in:International journal of biological macromolecules 2024-04, Vol.263, p.130694-130694, Article 130694
Main Authors: Wang, Rong, Zhang, Lan, Razzaq, Anam, Khan, Naveed Ullah, Alfaifi, Mohammad Y., Elbehairi, Serag Eldin I., Shati, Ali A., Iqbal, Haroon, Ni, Jiang
Format: Article
Language:English
Subjects:
biosafety
blood circulation
bovine serum albumin
BSA
cancer therapy
Cytotoxicity
drug therapy
electron microscopy
growth retardation
Heliotropium indicum
melanoma
nanoflowers
oxidative stress
plant extracts
ROS
Skin cancer
skin neoplasms
spectroscopy
zinc oxide
ZnO nanoflowers
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Summary:Zinc oxide (ZnO) has attracted a substantial interest in cancer research owing to their promising utility in cancer imaging and therapy. This study aimed to synthesized ZnO nanoflowers coated with albumin to actively target and the inhibit skin melanoma cells. We synthesized bovine serum albumin (BSA)-coated ZnO nanoflowers (BSA@ZnO NFs) and evaluated it's in vitro and in vivo therapeutic efficacy for skin cancer cells. BSA@ZnO NFs were prepared via single-step reduction method in the presence of plant extract (Heliotropium indicum) act as a capping agent, and further the successful fabrication was established by various physico-chemical characterizations, such as scanning electron microscopy (SEM), Fourier transform infra-red (FT-IR) spectroscopy, and x-rays diffraction (XRD) analysis. The fabricated BSA@ZnO NFs appeared flower like with multiple cone-shaped wings and average hydration size of 220.8 ± 12.6 nm. Further, BSA@ZnO NFs showed enhanced cellular uptake and cytocidal effects against skin cancer cells by inhibiting their growth via oxidative stress compared uncoated ZnO NFs. Moreover, BSA@ZnO NFs showed enhance biosafety, blood circulation time, tumor accumulation and in vivo tumor growth inhibition compared to ZnO NFs. In short, our findings suggesting BSA@ZnO NFs as a promising candidate for various types of cancer treatment along with chemotherapy. (a) Preparation scheme of BSA@ZnO NFs. (b) Tumor targeting mechanism of BSA@ZnO NFs. [Display omitted]
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2024.130694