Research progress of good markers for canine mammary carcinoma

• Published in: Molecular biology reports 2023-12, Vol.50 (12), p.10617-10625
• Main Authors: Yang, Ning-Yu, Zheng, Hui-Hua, Yu, Chao, Ye, Yan, Du, Chong-Tao, Xie, Guang-Hong
• Format: Article
• Language: English
• Subjects: Aged; Animal Anatomy; Animal Biochemistry; Animals; Antigens; Biomedical and Life Sciences; blood serum; BRCA1 protein; BRCA2 protein; Breast cancer; breast neoplasms; Breast Neoplasms - genetics; breasts; cadherins; Carcinoma - genetics; Cyclooxygenase 2 - genetics; Cyclooxygenase 2 - metabolism; Cyclooxygenase-2; Dog Diseases - diagnosis; Dog Diseases - genetics; Dog Diseases - metabolism; Dogs; E-cadherin; elderly; Epidermal growth factor; Epidermal growth factor receptors; ErbB-2 protein; erbB-2 receptor; Female; females; Gene Expression Regulation, Neoplastic; genes; Histology; Humans; Ki-67 Antigen - metabolism; Life Sciences; Mammary gland; mammary glands; Mammary Neoplasms, Animal - genetics; Mammary Neoplasms, Animal - metabolism; microRNA; MicroRNAs; MicroRNAs - genetics; miRNA; Morphology; p53 Protein; Proliferating cell nuclear antigen; prostaglandin synthase; Review; Tumor Suppressor Protein p53 - genetics; tumor suppressor proteins; Tumors
• ISSN: 0301-4851; 1573-4978
• DOI: 10.1007/s11033-023-08863-x

Purpose Mammary gland tumors are the most common neoplastic diseases in elderly female dogs, about 50% of which are considered to be malignant. Canine mammary tumors are similar to human breast cancers in many respects, so canine mammary tumors are frequently studied alongside human breast cancer. This article mentioned KI-67, HER-2, COX-2, BRCA1, BRCA2, P53, CA15-3, MicroRNA, Top2α and so on. All these markers are expected to have an important role in the clinic. Methods Existing markers of canine mammary carcinoma are reviewed, and the expression of each marker and its diagnostic role for this tumor are described in detail. Results This article introduced several effective markers of canine mammary tumors, among them, antigen KI-67 (KI-67), human epidermal growth factor receptor 2 (HER-2), cyclooxygenase 2 (COX-2) are promising and can be detected in both serum and tissue samples. Breast cancer caused by mutations in the breast cancer 1 gene (BRCA1) and breast cancer 2 gene (BRCA2) is also a hot topic of research. In addition to the above symbols, tumor protein p53 (p53), cancer antigen15-3 (CA15-3), MicroRNA (miRNA), topoisomerase πα (Top2α), proliferating cell nuclear antigen (PCNA), epidermal growth factor receptor (EGFR) and E-cadherin will also be involved in this paper. We will also mention Mammaglobin, which has been rarely reported so far. Graphical Abstract