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In Vivo Toxicity of Industrial Biocide Containing 2,2-Dibromo-3-nitrilopropionamide in Adult and Zebrafish Larvae
2,2-Dibromo-3-nitrilopropionamide (DBNPA) is a widely used biocide with potential environmental implications due to its toxicity. This study aimed to investigate the in vivo toxicity of DBNPA in zebrafish (Danio rerio), a model organism in environmental toxicology. Both adult and larval zebrafish we...
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| Published in: | Bulletin of environmental contamination and toxicology 2024-01, Vol.112 (1), p.2-2, Article 2 |
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| container_title | Bulletin of environmental contamination and toxicology |
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| creator | Pourshaban-Shahrestani, Ali Hassan, Jalal Koohi, Mohammad Kazem |
| description | 2,2-Dibromo-3-nitrilopropionamide (DBNPA) is a widely used biocide with potential environmental implications due to its toxicity. This study aimed to investigate the in vivo toxicity of DBNPA in zebrafish (Danio rerio), a model organism in environmental toxicology. Both adult and larval zebrafish were exposed to varying concentrations of DBNPA, and significant morphological changes and mortality rates were observed. The study found that even relatively low concentrations of DBNPA can have detrimental effects on zebrafish embryonic development, and high concentrations resulted in rapid mortality in adult zebrafish and larvae. The LC
50
values calculated from this study were 9.3 ppm for adults and 9.1 ppm for larvae, indicating the high toxicity of DBNPA to these organisms. These findings underscore the potential environmental impact of DBNPA and highlight the need for further research into its effects on aquatic ecosystems.
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| doi_str_mv | 10.1007/s00128-023-03824-3 |
| format | article |
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50
values calculated from this study were 9.3 ppm for adults and 9.1 ppm for larvae, indicating the high toxicity of DBNPA to these organisms. These findings underscore the potential environmental impact of DBNPA and highlight the need for further research into its effects on aquatic ecosystems.
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50
values calculated from this study were 9.3 ppm for adults and 9.1 ppm for larvae, indicating the high toxicity of DBNPA to these organisms. These findings underscore the potential environmental impact of DBNPA and highlight the need for further research into its effects on aquatic ecosystems.
Graphical Abstract</description><subject>adults</subject><subject>Animals</subject><subject>Aquatic ecosystems</subject><subject>Aquatic Pollution</subject><subject>Biocides</subject><subject>Biocompatibility</subject><subject>bulls</subject><subject>Calibration</subject><subject>Danio rerio</subject><subject>Disinfectants - toxicity</subject><subject>Earth and Environmental Science</subject><subject>Ecosystem</subject><subject>Ecotoxicology</subject><subject>Eggs</subject><subject>Embryo, Nonmammalian</subject><subject>Embryogenesis</subject><subject>Embryonic growth stage</subject><subject>Embryos</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Environmental impact</subject><subject>Females</subject><subject>In vivo methods and tests</subject><subject>Larva</subject><subject>Larvae</subject><subject>Low concentrations</subject><subject>Morphology</subject><subject>Mortality</subject><subject>Pollution</subject><subject>Skin</subject><subject>Soil Science & Conservation</subject><subject>Toxicity</subject><subject>Toxicology</subject><subject>Veterinary medicine</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollutants, Chemical - toxicity</subject><subject>Water Pollution Control</subject><subject>Zebrafish</subject><issn>0007-4861</issn><issn>1432-0800</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqF0U1PHCEYB3BiaupW_QIeGpJePBQLD9Bhjrr2ZZNNetEeeiEMMBYzAyvMmPrtZbvaJh7aEwd-z5-XP0InjJ4xSpsPhVIGilDghHIFgvA9tGCCA6GK0ldoQasiQn1kB-hNKbeVSwXwGh1wRVnDeLtAd6uIv4f7hK_Sr2DD9IBTj1fRzWXKwQz4IiQbnMfLFCcTYog3GN4DuQxdTmMinMRQ4ZA2OW1Cimbc4hDxuZuHCZvo8A_fZdOH8hOvTb43_gjt92Yo_vhpPUTXnz9dLb-S9bcvq-X5mlgu24m0vvecSdk7C9YDNNxK5RohvGGs71QjWtWKTtlOiobJrrfOedV2YJkRkhp-iE53ufVqd7Mvkx5DsX4YTPRpLrqGc9nUj1T_paBaCbJloqn03Qt6m-Yc60O2SmwDAaqCnbI5lZJ9rzc5jCY_aEb1tju9607X7vTv7jSvQ2-foudu9O7PyHNZFfAdKHUr3vj89-x_xD4Cw2qjeQ</recordid><startdate>20240101</startdate><enddate>20240101</enddate><creator>Pourshaban-Shahrestani, Ali</creator><creator>Hassan, Jalal</creator><creator>Koohi, Mohammad Kazem</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T7</scope><scope>7TK</scope><scope>7TV</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>P64</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>20240101</creationdate><title>In Vivo Toxicity of Industrial Biocide Containing 2,2-Dibromo-3-nitrilopropionamide in Adult and Zebrafish Larvae</title><author>Pourshaban-Shahrestani, Ali ; Hassan, Jalal ; Koohi, Mohammad Kazem</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-9efe3155fdc2ce2273c58d744ea11fb8749894b8cb54715bfcdde89b2c1a450a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>adults</topic><topic>Animals</topic><topic>Aquatic ecosystems</topic><topic>Aquatic Pollution</topic><topic>Biocides</topic><topic>Biocompatibility</topic><topic>bulls</topic><topic>Calibration</topic><topic>Danio rerio</topic><topic>Disinfectants - 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Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Bulletin of environmental contamination and toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pourshaban-Shahrestani, Ali</au><au>Hassan, Jalal</au><au>Koohi, Mohammad Kazem</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In Vivo Toxicity of Industrial Biocide Containing 2,2-Dibromo-3-nitrilopropionamide in Adult and Zebrafish Larvae</atitle><jtitle>Bulletin of environmental contamination and toxicology</jtitle><stitle>Bull Environ Contam Toxicol</stitle><addtitle>Bull Environ Contam Toxicol</addtitle><date>2024-01-01</date><risdate>2024</risdate><volume>112</volume><issue>1</issue><spage>2</spage><epage>2</epage><pages>2-2</pages><artnum>2</artnum><issn>0007-4861</issn><eissn>1432-0800</eissn><abstract>2,2-Dibromo-3-nitrilopropionamide (DBNPA) is a widely used biocide with potential environmental implications due to its toxicity. This study aimed to investigate the in vivo toxicity of DBNPA in zebrafish (Danio rerio), a model organism in environmental toxicology. Both adult and larval zebrafish were exposed to varying concentrations of DBNPA, and significant morphological changes and mortality rates were observed. The study found that even relatively low concentrations of DBNPA can have detrimental effects on zebrafish embryonic development, and high concentrations resulted in rapid mortality in adult zebrafish and larvae. The LC
50
values calculated from this study were 9.3 ppm for adults and 9.1 ppm for larvae, indicating the high toxicity of DBNPA to these organisms. These findings underscore the potential environmental impact of DBNPA and highlight the need for further research into its effects on aquatic ecosystems.
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| ispartof | Bulletin of environmental contamination and toxicology, 2024-01, Vol.112 (1), p.2-2, Article 2 |
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| subjects | adults Animals Aquatic ecosystems Aquatic Pollution Biocides Biocompatibility bulls Calibration Danio rerio Disinfectants - toxicity Earth and Environmental Science Ecosystem Ecotoxicology Eggs Embryo, Nonmammalian Embryogenesis Embryonic growth stage Embryos Environment Environmental Chemistry Environmental Health Environmental impact Females In vivo methods and tests Larva Larvae Low concentrations Morphology Mortality Pollution Skin Soil Science & Conservation Toxicity Toxicology Veterinary medicine Waste Water Technology Water Management Water Pollutants, Chemical - toxicity Water Pollution Control Zebrafish |
| title | In Vivo Toxicity of Industrial Biocide Containing 2,2-Dibromo-3-nitrilopropionamide in Adult and Zebrafish Larvae |
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