Myocardial plasma cell tumor with intratumoral amyloidosis in a dog

A 12-year-old mixed breed dog was evaluated for marked hypercalcemia that was identified during assessment for acute polydipsia and polyuria. Physical examination identified a new grade II/VI left apical systolic murmur. A mass involving the left ventricular posterior wall and left atrium was identi...

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Bibliographic Details
Published in:Journal of veterinary cardiology 2023-12, Vol.50, p.23-28
Main Authors: Alessandrino, K., Tjostheim, S.S., Flynn, K.M., Cole, C., Aschenbroich, S.
Format: Article
Language:English
Subjects:
amyloidosis
Amyloidosis - diagnosis
Amyloidosis - pathology
Amyloidosis - veterinary
Animals
clinical examination
Dog Diseases - diagnostic imaging
Dog Diseases - pathology
Dogs
echocardiography
Echocardiography - veterinary
Heart
hypercalcemia
Hyperglobulinemia
mixed breeds
myeloma
Myeloma-related disorders
myocardium
Myocardium - pathology
Neoplasia
patients
Plasmacytoma - pathology
Plasmacytoma - veterinary
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Summary:A 12-year-old mixed breed dog was evaluated for marked hypercalcemia that was identified during assessment for acute polydipsia and polyuria. Physical examination identified a new grade II/VI left apical systolic murmur. A mass involving the left ventricular posterior wall and left atrium was identified by echocardiography, suggesting neoplastic invasion into the myocardium. The patient was euthanized, and post-mortem cardiac evaluation identified an intramyocardial amyloid-producing plasma cell tumor. Multiple myeloma was suspected but could not be confirmed due to the limited post-mortem evaluation. This case is the first report of myocardial amyloidosis in a dog with a myeloma-related disorder (MRD). Dogs with MRD and myocardial involvement may not exhibit clinical signs that localize to the cardiovascular system; therefore, echocardiography should be considered during the staging process.
ISSN:1760-2734
1875-0834
DOI:10.1016/j.jvc.2023.09.004