Facet-dependent haloperoxidase-like activities of CeO2 nanoparticles contribute to their excellent biofilm formation suppression abilities

• Published in: Journal of hazardous materials 2024-03, Vol.465, p.133433, Article 133433
• Main Authors: Su, Dan, He, Xiaoyan, Zhou, Jiangwei, Yuan, Chengqing, Bai, Xiuqin
• Format: Article
• Language: English
• Subjects: Antibiofilm; biofilm; bromination; CeO2 nanoparticles; Facet; Haloperoxidase-like activity; nanoceria; nanorods; Quorum sensing signaling
• ISSN: 0304-3894; 1873-3336; 1873-3336
• DOI: 10.1016/j.jhazmat.2024.133433

Biofilms adhering to different surfaces have significant negative impacts in various fields. Cerium oxide nanoparticles can serve as mimics of haloperoxidase for biological biofilm inhibition applications. The regulation of the exposed facet of CeO2 nanoparticles influences their efficiency in various catalytic processes. However, there is still a lack of systematic studies on the facet-dependent haloperoxidase-like activity of CeO2. In the present study, the facet-dependent haloperoxidase activities and antibiofilm performance of CeO2 nanoparticles were elucidated through experiment analysis and density function theory calculation. The as-prepared CeO2 nanoparticles inhibited bacterial survival and catalyzed the oxidative bromination of quorum sensing signaling molecules, achieving biofilm inhibition performance. The antibacterial and biofilm formation suppression abilities were consistent with their haloperoxidase activities. The {111}- and {110}-facet CeO2 nanopolyhedra, as well as the {110}- and {100}-facet CeO2 nanorods, which had higher haloperoxidase activity showed better antibiofilm performance than the {100}-facet CeO2 cubes. The present findings provide a comprehensive understanding of the facet-dependent haloperoxidase-like activity of CeO2. Furthermore, engineering CeO2 morphologies with different crystal facets may represent a novel method for significantly adjusting their haloperoxidase-like activity. [Display omitted] •CeO2 nanoparticles with different exposed facets were used as haloperoxidases.•CeO2 nanopolyhedra exhibited the best haloperoxidase-like activity.•The haloperoxidase-like activities were elucidated by experiment and DFT analysis.•Haloperoxidase-like activity of CeO2 enhances its antibiofilm ability.