Clinical Characteristics, Treatment, and Outcomes of Veterans with Cerebrospinal Fluid Culture Positive for Gram-Negative Rod Bacteria: A Retrospective Analysis over 18 Years in 125 Veterans Health Administration Hospitals

Optimal management for patients with bacterial ventriculitis/meningitis due to Gram-negative rods (GNRs) has yet to be well investigated. We assessed the clinical characteristics, treatment, and outcomes of patients with a positive cerebrospinal fluid (CSF) culture for GNRs. We conducted a retrospec...

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Bibliographic Details
Published in:Current microbiology 2024-02, Vol.81 (2), p.70-70, Article 70
Main Authors: Hasegawa, Shinya, Matsumoto, Eiyu, Carlson, Jennifer R., Suzuki, Hiroyuki
Format: Article
Language:English
Subjects:
Bacteria
Biomedical and Life Sciences
Biotechnology
Cell culture
Cerebrospinal fluid
cohort studies
Contamination
Gram-negative bacteria
Health services
Hospitals
leukocyte count
Leukocytes (neutrophilic)
Life Sciences
Meningitis
Microbiology
mortality
neutrophils
Patients
retrospective studies
Ventriculitis
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Summary:Optimal management for patients with bacterial ventriculitis/meningitis due to Gram-negative rods (GNRs) has yet to be well investigated. We assessed the clinical characteristics, treatment, and outcomes of patients with a positive cerebrospinal fluid (CSF) culture for GNRs. We conducted a retrospective cohort study of all patients with a positive CSF culture within the Veterans Health Administration (VHA) system during 2003–2020. Clinical and microbiological characteristics between the true meningitis and contamination groups were compared. Of the 5919 patients with positive CSF cultures among 125 nationwide VHA acute-care hospitals, 297 (5.0%) were positive for GNRs. Among 262 patients analyzed, 156 (59.5%) were assessed as patients with true meningitis, and 106 (40.5%) were assessed as patients with contaminated CSF cultures. Patients with true meningitis had a significantly higher CSF protein (median 168 vs 57 mg/dL, p  
ISSN:0343-8651
1432-0991
DOI:10.1007/s00284-023-03593-6