Palladium-Catalyzed Denitrative Synthesis of Aryl Nitriles from Nitroarenes and Organocyanides

A denitrative cyanation of nitroarenes using organocyanides and a palladium catalyst was developed. The key for this reaction was the utilization of an aminoacetonitrile as a cyano source to avoid the generation of stoichiometric metal- and halogen-containing chemical waste. A wide range of nitroare...

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Published in:Organic letters 2024-05, Vol.26 (18), p.3977-3981
Main Authors: Iizumi, Keiichiro, Tanaka, Hiroki, Muto, Kei, Yamaguchi, Junichiro
Format: Article
Language:English
Subjects:
catalysts
nitriles
nitroaromatic compounds
palladium
stoichiometry
wastes
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cited_by cdi_FETCH-LOGICAL-a378t-fcdba4cba011142fb7f452c52f4ad22af168b86bb56de7b4f4478c836a33eea63
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container_title Organic letters
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creator Iizumi, Keiichiro
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Yamaguchi, Junichiro
description A denitrative cyanation of nitroarenes using organocyanides and a palladium catalyst was developed. The key for this reaction was the utilization of an aminoacetonitrile as a cyano source to avoid the generation of stoichiometric metal- and halogen-containing chemical waste. A wide range of nitroarenes, including heteroarenes and pharmaceutical molecules, can be converted into aryl nitriles.
doi_str_mv 10.1021/acs.orglett.4c01118
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source American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list)
subjects catalysts
nitriles
nitroaromatic compounds
palladium
stoichiometry
wastes
title Palladium-Catalyzed Denitrative Synthesis of Aryl Nitriles from Nitroarenes and Organocyanides
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