Exposure to per- and polyfluoroalkyl substance and metabolic syndrome: A nationally representative cross-sectional study from NHANES, 2003–2018

Per- and polyfluoroalkyl substances(PFAS) are widespread organic pollutants with endocrine-disrupting effects on human health, but the association of PFAS exposure with metabolic syndrome remains conflicting. National Health and Nutrition Examination Survey(NHANES) program was utilized to evaluate t...

Full description

Saved in:
Bibliographic Details
Published in:Environmental pollution (1987) 2024-04, Vol.346, p.123615-123615, Article 123615
Main Authors: Wu, Maolan, Zhu, Zewu, Wan, Rongjun, Xu, Jiangyue
Format: Article
Language:English
Subjects:
Alkanesulfonic Acids
Cross-Sectional Studies
Cross-sectional study
Environmental Pollutants
fatty liver
Female
Fluorocarbons
gender
human health
Humans
Hyperglycemia
hyperlipidemia
Hyperlipidemias
hypertension
Male
Metabolic syndrome
Metabolic Syndrome - epidemiology
National Health and Nutrition Examination Survey
NHANES
Non-alcoholic Fatty Liver Disease
Nutrition Surveys
Obesity
Perfluoroalkyl substance
perfluorohexane sulfonic acid
pollution
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Per- and polyfluoroalkyl substances(PFAS) are widespread organic pollutants with endocrine-disrupting effects on human health, but the association of PFAS exposure with metabolic syndrome remains conflicting. National Health and Nutrition Examination Survey(NHANES) program was utilized to evaluate the association of individual PFAS exposure and metabolic disorders and further determined the joint effect of PFAS co-exposures. 13921 participants and five PFAS exposures(PFHxS, MPAH, PFDE, PFNA, and PFUA) were included for analysis. The association between individual PFAS and metabolic syndrome varied in the specific PFAS and the specific metabolic disorder examined. PFHxS was negatively associated with obesity(Q4; OR = 0.75; P 
ISSN:0269-7491
1873-6424
DOI:10.1016/j.envpol.2024.123615