Multi-layered genome defences in bacteria

Bacteria have evolved a variety of defence mechanisms to protect against mobile genetic elements, including restriction-modification systems and CRISPR–Cas. In recent years, dozens of previously unknown defence systems (DSs) have been discovered. Notably, diverse DSs often coexist within the same ge...

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Bibliographic Details
Published in:Current opinion in microbiology 2024-04, Vol.78, p.102436-102436, Article 102436
Main Authors: Agapov, Aleksei, Baker, Kate S, Bedekar, Paritosh, Bhatia, Rama P, Blower, Tim R, Brockhurst, Michael A, Brown, Cooper, Chong, Charlotte E, Fothergill, Joanne L, Graham, Shirley, Hall, James PJ, Maestri, Alice, McQuarrie, Stuart, Olina, Anna, Pagliara, Stefano, Recker, Mario, Richmond, Anna, Shaw, Steven J, Szczelkun, Mark D, Taylor, Tiffany B, van Houte, Stineke, Went, Sam C, Westra, Edze R, White, Malcolm F, Wright, Rosanna
Format: Article
Language:English
Subjects:
CRISPR-Cas systems
genome
microbiology
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Summary:Bacteria have evolved a variety of defence mechanisms to protect against mobile genetic elements, including restriction-modification systems and CRISPR–Cas. In recent years, dozens of previously unknown defence systems (DSs) have been discovered. Notably, diverse DSs often coexist within the same genome, and some co-occur at frequencies significantly higher than would be expected by chance, implying potential synergistic interactions. Recent studies have provided evidence of defence mechanisms that enhance or complement one another. Here, we review the interactions between DSs at the mechanistic, regulatory, ecological and evolutionary levels.
ISSN:1369-5274
1879-0364
DOI:10.1016/j.mib.2024.102436