Gapless biosynthetic pathway enables sustainable paclitaxel production

A recent leading-edge study by Jiang et al. identified two enzymes that are responsible for key reactions in the biosynthesis of baccatin III. The authors successfully reconstructed the baccatin III synthesis pathway with a minimal number of synthetic enzymes in tobacco leaves, laying the foundation...

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Bibliographic Details
Published in:Trends in plant science 2024-09, Vol.29 (9), p.948-951
Main Authors: Xue, Chengfeng, Zhang, Meng, Yao, Ruifeng
Format: Article
Language:English
Subjects:
antineoplastic agents
baccatin III biosynthesis
biochemical pathways
biosynthesis
cytochrome P450 enzyme
oxetane formation
paclitaxel
Taxus
tobacco
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Summary:A recent leading-edge study by Jiang et al. identified two enzymes that are responsible for key reactions in the biosynthesis of baccatin III. The authors successfully reconstructed the baccatin III synthesis pathway with a minimal number of synthetic enzymes in tobacco leaves, laying the foundation for industrial-scale sustainable production of the anticancer drug paclitaxel. A recent leading-edge study by Jiang et al. identified two enzymes that are responsible for key reactions in the biosynthesis of baccatin III. The authors successfully reconstructed the baccatin III synthesis pathway with a minimal number of synthetic enzymes in tobacco leaves, laying the foundation for industrial-scale sustainable production of the anticancer drug paclitaxel.
ISSN:1360-1385
1878-4372
1878-4372
DOI:10.1016/j.tplants.2024.05.005