Navigating the terrain of neutrophil extracellular traps in severe malaria pathogenesis

Du, Ren, et al. recently showed in a Plasmodium berghei ANKA (PbA) experimental malaria model that phosphatase of regenerating liver 2 (PRL2) regulates neutrophil extracellular traps (NETs) in severe malaria (SM)-related acute lung injury (ALI). PRL2 deficiency caused SM with ALI in a mouse model by...

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Bibliographic Details
Published in:Trends in parasitology 2024-04, Vol.40 (4), p.278-279
Main Authors: Saeed, Maria, Aitken, Elizabeth H., Rogerson, Stephen J.
Format: Article
Language:English
Subjects:
acute lung injury
landscapes
liver
lungs
malaria
mice
murine malaria
neutrophil extracellular traps (NETs)
neutrophils
parasitology
pathogenesis
Plasmodium berghei
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Summary:Du, Ren, et al. recently showed in a Plasmodium berghei ANKA (PbA) experimental malaria model that phosphatase of regenerating liver 2 (PRL2) regulates neutrophil extracellular traps (NETs) in severe malaria (SM)-related acute lung injury (ALI). PRL2 deficiency caused SM with ALI in a mouse model by increasing NETs in pulmonary tissue; hydroxychloroquine (HCQ) may ameliorate this. Du, Ren, et al. recently showed in a Plasmodium berghei ANKA (PbA) experimental malaria model that phosphatase of regenerating liver 2 (PRL2) regulates neutrophil extracellular traps (NETs) in severe malaria (SM)-related acute lung injury (ALI). PRL2 deficiency caused SM with ALI in a mouse model by increasing NETs in pulmonary tissue; hydroxychloroquine (HCQ) may ameliorate this.
ISSN:1471-4922
1471-5007
DOI:10.1016/j.pt.2024.03.001