Examination of the utility of skin carotenoid status in estimating dietary intakes of carotenoids and fruits and vegetables: A randomized, parallel-group, controlled feeding trial

•Skin carotenoids are positively correlated with fruit and vegetable intake.•Skin carotenoids reflect changes in dietary carotenoid intake.•Skin carotenoids can be a valid biomarker for fruit and vegetable intake. Optical spectroscopy-measured skin carotenoid status (SCS) has been validated for esti...

Full description

Saved in:
Bibliographic Details
Published in:Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2024-03, Vol.119, p.112304-112304, Article 112304
Main Authors: Ahn, Seoeun, Hwang, Jeong-Eun, Kim, Yoon Jae, Eom, Kunsun, Jung, Myoung Hoon, Moon, HyunSeok, Ham, Dongwoo, Park, Ji Min, Oh, Se Uk, Park, Jin-Young, Joung, Hyojee
Format: Article
Language:English
Subjects:
Alcohol use
Biomarker
Biomarkers
blood serum
Body mass index
Cardiovascular disease
Carotenoid kinetics
Carotenoids
clinical trials
Correlation analysis
Diabetes
Diet
Dietary intervention
equations
Feeding
Food allergies
Food intake
Fruits
High performance liquid chromatography
Kinetics
Liquid chromatography
Metabolic disorders
Raman spectroscopy
Resonance Raman spectroscopy
Skin
Spectroscopic analysis
Spectroscopy
Spectrum analysis
Validation
Vegetables
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c366t-32b2787019ea7d8534fc0a2a4b3b23686a516f686268182fe92b40efd9a3847a3
container_end_page 112304
container_issue
container_start_page 112304
container_title Nutrition (Burbank, Los Angeles County, Calif.)
container_volume 119
creator Ahn, Seoeun
Hwang, Jeong-Eun
Kim, Yoon Jae
Eom, Kunsun
Jung, Myoung Hoon
Moon, HyunSeok
Ham, Dongwoo
Park, Ji Min
Oh, Se Uk
Park, Jin-Young
Joung, Hyojee
description •Skin carotenoids are positively correlated with fruit and vegetable intake.•Skin carotenoids reflect changes in dietary carotenoid intake.•Skin carotenoids can be a valid biomarker for fruit and vegetable intake. Optical spectroscopy-measured skin carotenoid status (SCS) has been validated for estimating fruit and vegetable (F&V) intake; however, there is limited research addressing SCS kinetics in whole-diet interventions. The aim of this controlled feeding trial was to explore SCS's response to carotenoid intake changes via whole-diet intervention, evaluating its biomarker potential. Eighty participants ages 20 to 49 y, without underlying diseases, were randomly allocated to the high-carotenoid group (HG; n = 40) or control group (CG; n = 40). The HG consumed a high-carotenoid diet (21 mg total carotenoids/2000 kcal), whereas the CG consumed a control diet (13.6 mg total carotenoids/2000 kcal) for 6 wk. Subsequently, skin and blood carotenoid concentrations were tracked without intervention for 4 wk. SCS was measured weekly via resonance Raman spectroscopy, and serum carotenoid concentrations were analyzed biweekly using high-performance liquid chromatography. Baseline carotenoid and F&V intakes were assessed via a 3-d diet record. The kinetics of SCS and serum carotenoid concentrations were analyzed using a weighted generalized estimating equation. Pearson's correlation analyses were used to examine baseline correlations between SCS and dietary carotenoid and F&V intakes, as well as serum carotenoid concentrations. During the intervention, the HG showed a faster and greater SCS increase than the CG (difference in slope per week = 8.87 AU, Pinteraction
doi_str_mv 10.1016/j.nut.2023.112304
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3153631541</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0899900723003325</els_id><sourcerecordid>3153631541</sourcerecordid><originalsourceid>FETCH-LOGICAL-c366t-32b2787019ea7d8534fc0a2a4b3b23686a516f686268182fe92b40efd9a3847a3</originalsourceid><addsrcrecordid>eNqFkctu1TAQhi0EoqeFB2CDLLFh0Rx8y8V0VVXlIlViA2vLSSYHnyb2wXYqDq_FC3aiFJBYwMZj__r-sWZ-Ql5wtuWMV2_2Wz_nrWBCbjkXkqlHZMObWhZcKPWYbFijdaEZq0_IaUp7xhjXlX5KTmTDSyV1vSE_r7_byXmbXfA0DDR_BTpnN7p8XJ7p1nna2Rgy-OB6mrLNc6IoQspuQpvf0d5BtvGIara3kBbfH0ui1vd0iLPL6_UOdoi3I6S39JJGlMLkfkB_Tg822nGEsdjFMB_OaRd8jgEV9AP0y1c5Ojs-I08GOyZ4_lDPyJd315-vPhQ3n95_vLq8KTpZVbmQohV1U-PMYOu-KaUaOmaFVa1shayaypa8GrCKquGNGECLVjEYem1lo2orz8jrte8hhm8zDmwmlzoYR-shzMlIXsoKD8X_iwrNGkyoFBrRV3-h-zBHj4MgJaSUQtQKKb5SXQwpRRjMIeK-49FwZpbwzd5g-GYJ36zho-flQ-e5naD_7fiVNgIXKwC4tTsH0aTOge9wtxG6bPrg_tH-Hs14wac</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2923332274</pqid></control><display><type>article</type><title>Examination of the utility of skin carotenoid status in estimating dietary intakes of carotenoids and fruits and vegetables: A randomized, parallel-group, controlled feeding trial</title><source>ScienceDirect Freedom Collection</source><creator>Ahn, Seoeun ; Hwang, Jeong-Eun ; Kim, Yoon Jae ; Eom, Kunsun ; Jung, Myoung Hoon ; Moon, HyunSeok ; Ham, Dongwoo ; Park, Ji Min ; Oh, Se Uk ; Park, Jin-Young ; Joung, Hyojee</creator><creatorcontrib>Ahn, Seoeun ; Hwang, Jeong-Eun ; Kim, Yoon Jae ; Eom, Kunsun ; Jung, Myoung Hoon ; Moon, HyunSeok ; Ham, Dongwoo ; Park, Ji Min ; Oh, Se Uk ; Park, Jin-Young ; Joung, Hyojee</creatorcontrib><description><![CDATA[•Skin carotenoids are positively correlated with fruit and vegetable intake.•Skin carotenoids reflect changes in dietary carotenoid intake.•Skin carotenoids can be a valid biomarker for fruit and vegetable intake. Optical spectroscopy-measured skin carotenoid status (SCS) has been validated for estimating fruit and vegetable (F&V) intake; however, there is limited research addressing SCS kinetics in whole-diet interventions. The aim of this controlled feeding trial was to explore SCS's response to carotenoid intake changes via whole-diet intervention, evaluating its biomarker potential. Eighty participants ages 20 to 49 y, without underlying diseases, were randomly allocated to the high-carotenoid group (HG; n = 40) or control group (CG; n = 40). The HG consumed a high-carotenoid diet (21 mg total carotenoids/2000 kcal), whereas the CG consumed a control diet (13.6 mg total carotenoids/2000 kcal) for 6 wk. Subsequently, skin and blood carotenoid concentrations were tracked without intervention for 4 wk. SCS was measured weekly via resonance Raman spectroscopy, and serum carotenoid concentrations were analyzed biweekly using high-performance liquid chromatography. Baseline carotenoid and F&V intakes were assessed via a 3-d diet record. The kinetics of SCS and serum carotenoid concentrations were analyzed using a weighted generalized estimating equation. Pearson's correlation analyses were used to examine baseline correlations between SCS and dietary carotenoid and F&V intakes, as well as serum carotenoid concentrations. During the intervention, the HG showed a faster and greater SCS increase than the CG (difference in slope per week = 8.87 AU, Pinteraction <0.001). Baseline SCS had positive correlations with total carotenoid intake (r = 0.45), total F&V intake (r = 0.49), and total serum carotenoid concentration (r = 0.79; P < 0.001 for all). These results suggest that SCS is a valid biomarker for monitoring changes in carotenoid intake through whole diet, which supports using SCS for assessing carotenoid-rich F&V intake.]]></description><identifier>ISSN: 0899-9007</identifier><identifier>EISSN: 1873-1244</identifier><identifier>DOI: 10.1016/j.nut.2023.112304</identifier><identifier>PMID: 38154397</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Alcohol use ; Biomarker ; Biomarkers ; blood serum ; Body mass index ; Cardiovascular disease ; Carotenoid kinetics ; Carotenoids ; clinical trials ; Correlation analysis ; Diabetes ; Diet ; Dietary intervention ; equations ; Feeding ; Food allergies ; Food intake ; Fruits ; High performance liquid chromatography ; Kinetics ; Liquid chromatography ; Metabolic disorders ; Raman spectroscopy ; Resonance Raman spectroscopy ; Skin ; Spectroscopic analysis ; Spectroscopy ; Spectrum analysis ; Validation ; Vegetables</subject><ispartof>Nutrition (Burbank, Los Angeles County, Calif.), 2024-03, Vol.119, p.112304-112304, Article 112304</ispartof><rights>2023 Elsevier Inc.</rights><rights>Copyright © 2023 Elsevier Inc. All rights reserved.</rights><rights>2023. Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c366t-32b2787019ea7d8534fc0a2a4b3b23686a516f686268182fe92b40efd9a3847a3</cites><orcidid>0000-0003-2433-2280 ; 0000-0002-9968-9391 ; 0000-0003-1182-7786 ; 0000-0002-5448-1749 ; 0000-0002-7890-1509</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38154397$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ahn, Seoeun</creatorcontrib><creatorcontrib>Hwang, Jeong-Eun</creatorcontrib><creatorcontrib>Kim, Yoon Jae</creatorcontrib><creatorcontrib>Eom, Kunsun</creatorcontrib><creatorcontrib>Jung, Myoung Hoon</creatorcontrib><creatorcontrib>Moon, HyunSeok</creatorcontrib><creatorcontrib>Ham, Dongwoo</creatorcontrib><creatorcontrib>Park, Ji Min</creatorcontrib><creatorcontrib>Oh, Se Uk</creatorcontrib><creatorcontrib>Park, Jin-Young</creatorcontrib><creatorcontrib>Joung, Hyojee</creatorcontrib><title>Examination of the utility of skin carotenoid status in estimating dietary intakes of carotenoids and fruits and vegetables: A randomized, parallel-group, controlled feeding trial</title><title>Nutrition (Burbank, Los Angeles County, Calif.)</title><addtitle>Nutrition</addtitle><description><![CDATA[•Skin carotenoids are positively correlated with fruit and vegetable intake.•Skin carotenoids reflect changes in dietary carotenoid intake.•Skin carotenoids can be a valid biomarker for fruit and vegetable intake. Optical spectroscopy-measured skin carotenoid status (SCS) has been validated for estimating fruit and vegetable (F&V) intake; however, there is limited research addressing SCS kinetics in whole-diet interventions. The aim of this controlled feeding trial was to explore SCS's response to carotenoid intake changes via whole-diet intervention, evaluating its biomarker potential. Eighty participants ages 20 to 49 y, without underlying diseases, were randomly allocated to the high-carotenoid group (HG; n = 40) or control group (CG; n = 40). The HG consumed a high-carotenoid diet (21 mg total carotenoids/2000 kcal), whereas the CG consumed a control diet (13.6 mg total carotenoids/2000 kcal) for 6 wk. Subsequently, skin and blood carotenoid concentrations were tracked without intervention for 4 wk. SCS was measured weekly via resonance Raman spectroscopy, and serum carotenoid concentrations were analyzed biweekly using high-performance liquid chromatography. Baseline carotenoid and F&V intakes were assessed via a 3-d diet record. The kinetics of SCS and serum carotenoid concentrations were analyzed using a weighted generalized estimating equation. Pearson's correlation analyses were used to examine baseline correlations between SCS and dietary carotenoid and F&V intakes, as well as serum carotenoid concentrations. During the intervention, the HG showed a faster and greater SCS increase than the CG (difference in slope per week = 8.87 AU, Pinteraction <0.001). Baseline SCS had positive correlations with total carotenoid intake (r = 0.45), total F&V intake (r = 0.49), and total serum carotenoid concentration (r = 0.79; P < 0.001 for all). These results suggest that SCS is a valid biomarker for monitoring changes in carotenoid intake through whole diet, which supports using SCS for assessing carotenoid-rich F&V intake.]]></description><subject>Alcohol use</subject><subject>Biomarker</subject><subject>Biomarkers</subject><subject>blood serum</subject><subject>Body mass index</subject><subject>Cardiovascular disease</subject><subject>Carotenoid kinetics</subject><subject>Carotenoids</subject><subject>clinical trials</subject><subject>Correlation analysis</subject><subject>Diabetes</subject><subject>Diet</subject><subject>Dietary intervention</subject><subject>equations</subject><subject>Feeding</subject><subject>Food allergies</subject><subject>Food intake</subject><subject>Fruits</subject><subject>High performance liquid chromatography</subject><subject>Kinetics</subject><subject>Liquid chromatography</subject><subject>Metabolic disorders</subject><subject>Raman spectroscopy</subject><subject>Resonance Raman spectroscopy</subject><subject>Skin</subject><subject>Spectroscopic analysis</subject><subject>Spectroscopy</subject><subject>Spectrum analysis</subject><subject>Validation</subject><subject>Vegetables</subject><issn>0899-9007</issn><issn>1873-1244</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFkctu1TAQhi0EoqeFB2CDLLFh0Rx8y8V0VVXlIlViA2vLSSYHnyb2wXYqDq_FC3aiFJBYwMZj__r-sWZ-Ql5wtuWMV2_2Wz_nrWBCbjkXkqlHZMObWhZcKPWYbFijdaEZq0_IaUp7xhjXlX5KTmTDSyV1vSE_r7_byXmbXfA0DDR_BTpnN7p8XJ7p1nna2Rgy-OB6mrLNc6IoQspuQpvf0d5BtvGIara3kBbfH0ui1vd0iLPL6_UOdoi3I6S39JJGlMLkfkB_Tg822nGEsdjFMB_OaRd8jgEV9AP0y1c5Ojs-I08GOyZ4_lDPyJd315-vPhQ3n95_vLq8KTpZVbmQohV1U-PMYOu-KaUaOmaFVa1shayaypa8GrCKquGNGECLVjEYem1lo2orz8jrte8hhm8zDmwmlzoYR-shzMlIXsoKD8X_iwrNGkyoFBrRV3-h-zBHj4MgJaSUQtQKKb5SXQwpRRjMIeK-49FwZpbwzd5g-GYJ36zho-flQ-e5naD_7fiVNgIXKwC4tTsH0aTOge9wtxG6bPrg_tH-Hs14wac</recordid><startdate>20240301</startdate><enddate>20240301</enddate><creator>Ahn, Seoeun</creator><creator>Hwang, Jeong-Eun</creator><creator>Kim, Yoon Jae</creator><creator>Eom, Kunsun</creator><creator>Jung, Myoung Hoon</creator><creator>Moon, HyunSeok</creator><creator>Ham, Dongwoo</creator><creator>Park, Ji Min</creator><creator>Oh, Se Uk</creator><creator>Park, Jin-Young</creator><creator>Joung, Hyojee</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RQ</scope><scope>7RV</scope><scope>7TS</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0003-2433-2280</orcidid><orcidid>https://orcid.org/0000-0002-9968-9391</orcidid><orcidid>https://orcid.org/0000-0003-1182-7786</orcidid><orcidid>https://orcid.org/0000-0002-5448-1749</orcidid><orcidid>https://orcid.org/0000-0002-7890-1509</orcidid></search><sort><creationdate>20240301</creationdate><title>Examination of the utility of skin carotenoid status in estimating dietary intakes of carotenoids and fruits and vegetables: A randomized, parallel-group, controlled feeding trial</title><author>Ahn, Seoeun ; Hwang, Jeong-Eun ; Kim, Yoon Jae ; Eom, Kunsun ; Jung, Myoung Hoon ; Moon, HyunSeok ; Ham, Dongwoo ; Park, Ji Min ; Oh, Se Uk ; Park, Jin-Young ; Joung, Hyojee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366t-32b2787019ea7d8534fc0a2a4b3b23686a516f686268182fe92b40efd9a3847a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Alcohol use</topic><topic>Biomarker</topic><topic>Biomarkers</topic><topic>blood serum</topic><topic>Body mass index</topic><topic>Cardiovascular disease</topic><topic>Carotenoid kinetics</topic><topic>Carotenoids</topic><topic>clinical trials</topic><topic>Correlation analysis</topic><topic>Diabetes</topic><topic>Diet</topic><topic>Dietary intervention</topic><topic>equations</topic><topic>Feeding</topic><topic>Food allergies</topic><topic>Food intake</topic><topic>Fruits</topic><topic>High performance liquid chromatography</topic><topic>Kinetics</topic><topic>Liquid chromatography</topic><topic>Metabolic disorders</topic><topic>Raman spectroscopy</topic><topic>Resonance Raman spectroscopy</topic><topic>Skin</topic><topic>Spectroscopic analysis</topic><topic>Spectroscopy</topic><topic>Spectrum analysis</topic><topic>Validation</topic><topic>Vegetables</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahn, Seoeun</creatorcontrib><creatorcontrib>Hwang, Jeong-Eun</creatorcontrib><creatorcontrib>Kim, Yoon Jae</creatorcontrib><creatorcontrib>Eom, Kunsun</creatorcontrib><creatorcontrib>Jung, Myoung Hoon</creatorcontrib><creatorcontrib>Moon, HyunSeok</creatorcontrib><creatorcontrib>Ham, Dongwoo</creatorcontrib><creatorcontrib>Park, Ji Min</creatorcontrib><creatorcontrib>Oh, Se Uk</creatorcontrib><creatorcontrib>Park, Jin-Young</creatorcontrib><creatorcontrib>Joung, Hyojee</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Career and Technical Education (ProQuest Database)</collection><collection>ProQuest Nursing &amp; Allied Health Database</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>ProQuest - Health &amp; Medical Complete保健、医学与药学数据库</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>British Nursing Index</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Biological Sciences</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>ProQuest Healthcare Administration Database</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest research library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health &amp; Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health &amp; Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied &amp; Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahn, Seoeun</au><au>Hwang, Jeong-Eun</au><au>Kim, Yoon Jae</au><au>Eom, Kunsun</au><au>Jung, Myoung Hoon</au><au>Moon, HyunSeok</au><au>Ham, Dongwoo</au><au>Park, Ji Min</au><au>Oh, Se Uk</au><au>Park, Jin-Young</au><au>Joung, Hyojee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Examination of the utility of skin carotenoid status in estimating dietary intakes of carotenoids and fruits and vegetables: A randomized, parallel-group, controlled feeding trial</atitle><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle><addtitle>Nutrition</addtitle><date>2024-03-01</date><risdate>2024</risdate><volume>119</volume><spage>112304</spage><epage>112304</epage><pages>112304-112304</pages><artnum>112304</artnum><issn>0899-9007</issn><eissn>1873-1244</eissn><abstract><![CDATA[•Skin carotenoids are positively correlated with fruit and vegetable intake.•Skin carotenoids reflect changes in dietary carotenoid intake.•Skin carotenoids can be a valid biomarker for fruit and vegetable intake. Optical spectroscopy-measured skin carotenoid status (SCS) has been validated for estimating fruit and vegetable (F&V) intake; however, there is limited research addressing SCS kinetics in whole-diet interventions. The aim of this controlled feeding trial was to explore SCS's response to carotenoid intake changes via whole-diet intervention, evaluating its biomarker potential. Eighty participants ages 20 to 49 y, without underlying diseases, were randomly allocated to the high-carotenoid group (HG; n = 40) or control group (CG; n = 40). The HG consumed a high-carotenoid diet (21 mg total carotenoids/2000 kcal), whereas the CG consumed a control diet (13.6 mg total carotenoids/2000 kcal) for 6 wk. Subsequently, skin and blood carotenoid concentrations were tracked without intervention for 4 wk. SCS was measured weekly via resonance Raman spectroscopy, and serum carotenoid concentrations were analyzed biweekly using high-performance liquid chromatography. Baseline carotenoid and F&V intakes were assessed via a 3-d diet record. The kinetics of SCS and serum carotenoid concentrations were analyzed using a weighted generalized estimating equation. Pearson's correlation analyses were used to examine baseline correlations between SCS and dietary carotenoid and F&V intakes, as well as serum carotenoid concentrations. During the intervention, the HG showed a faster and greater SCS increase than the CG (difference in slope per week = 8.87 AU, Pinteraction <0.001). Baseline SCS had positive correlations with total carotenoid intake (r = 0.45), total F&V intake (r = 0.49), and total serum carotenoid concentration (r = 0.79; P < 0.001 for all). These results suggest that SCS is a valid biomarker for monitoring changes in carotenoid intake through whole diet, which supports using SCS for assessing carotenoid-rich F&V intake.]]></abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>38154397</pmid><doi>10.1016/j.nut.2023.112304</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-2433-2280</orcidid><orcidid>https://orcid.org/0000-0002-9968-9391</orcidid><orcidid>https://orcid.org/0000-0003-1182-7786</orcidid><orcidid>https://orcid.org/0000-0002-5448-1749</orcidid><orcidid>https://orcid.org/0000-0002-7890-1509</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 0899-9007
ispartof Nutrition (Burbank, Los Angeles County, Calif.), 2024-03, Vol.119, p.112304-112304, Article 112304
issn 0899-9007
1873-1244
language eng
recordid cdi_proquest_miscellaneous_3153631541
source ScienceDirect Freedom Collection
subjects Alcohol use
Biomarker
Biomarkers
blood serum
Body mass index
Cardiovascular disease
Carotenoid kinetics
Carotenoids
clinical trials
Correlation analysis
Diabetes
Diet
Dietary intervention
equations
Feeding
Food allergies
Food intake
Fruits
High performance liquid chromatography
Kinetics
Liquid chromatography
Metabolic disorders
Raman spectroscopy
Resonance Raman spectroscopy
Skin
Spectroscopic analysis
Spectroscopy
Spectrum analysis
Validation
Vegetables
title Examination of the utility of skin carotenoid status in estimating dietary intakes of carotenoids and fruits and vegetables: A randomized, parallel-group, controlled feeding trial
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-22T10%3A12%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Examination%20of%20the%20utility%20of%20skin%20carotenoid%20status%20in%20estimating%20dietary%20intakes%20of%20carotenoids%20and%20fruits%20and%20vegetables:%20A%20randomized,%20parallel-group,%20controlled%20feeding%20trial&rft.jtitle=Nutrition%20(Burbank,%20Los%20Angeles%20County,%20Calif.)&rft.au=Ahn,%20Seoeun&rft.date=2024-03-01&rft.volume=119&rft.spage=112304&rft.epage=112304&rft.pages=112304-112304&rft.artnum=112304&rft.issn=0899-9007&rft.eissn=1873-1244&rft_id=info:doi/10.1016/j.nut.2023.112304&rft_dat=%3Cproquest_cross%3E3153631541%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c366t-32b2787019ea7d8534fc0a2a4b3b23686a516f686268182fe92b40efd9a3847a3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2923332274&rft_id=info:pmid/38154397&rfr_iscdi=true