A leaky gut contributes to postural imbalance in male patients with chronic obstructive pulmonary disease

Patients with chronic obstructive pulmonary disease (COPD) frequently exhibit an inability to maintain postural balance. However, the contribution of increased intestinal permeability or leaky gut to the postural imbalance in COPD is not known. We measured plasma zonulin, a marker of leaky gut, with...

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Bibliographic Details
Published in:Clinical nutrition ESPEN 2024-08, Vol.62, p.157-163
Main Authors: Qaisar, Rizwan, Hussain, Shah, Karim, Asima, Muhammad, Tahir, Ustrana, Shahjahan, Azhar Hussain, M., Ahmad, Firdos
Format: Article
Language:English
Subjects:
Aged
Biomarkers - blood
C-Reactive Protein - metabolism
Case-Control Studies
Cholera Toxin - blood
Chronic obstructive pulmonary disease
clinical nutrition
Dinoprost - analogs & derivatives
exercise test
gait
Hand Strength
Handgrip strength
Haptoglobins
Humans
inflammation
intestines
Leaky gut
Male
males
Middle Aged
oxidative stress
Permeability
Postural Balance
Postural imbalance
Protein Precursors - blood
Pulmonary Disease, Chronic Obstructive - blood
Pulmonary Disease, Chronic Obstructive - physiopathology
respiratory tract diseases
therapeutics
Zonulin
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Summary:Patients with chronic obstructive pulmonary disease (COPD) frequently exhibit an inability to maintain postural balance. However, the contribution of increased intestinal permeability or leaky gut to the postural imbalance in COPD is not known. We measured plasma zonulin, a marker of leaky gut, with relevance to postural balance in male controls (n = 70) and patients with mild (n = 67), moderate (n = 66), and severe (n = 58) COPD. We employed a short physical performance battery to evaluate postural balance in supine, tandem, and semi-tandem positions. We also measured handgrip strength (HGS), gait speed, plasma c-reactive proteins (CRP), and 8-isoprostanes as potential mechanistic connections between postural imbalance and leaky gut. COPD patients demonstrated higher plasma zonulin, CRP, and 8-isoprostanes levels and lower balance, HGS, and gait speed than controls (all p 
ISSN:2405-4577
2405-4577
DOI:10.1016/j.clnesp.2024.05.018