Oxidative Free-Radical C(sp2)–H Bond Chlorination of Enaminones with LiCl: Access to Highly Functionalized α‑Chlorinated Enaminones

An oxidative free-radical C­(sp2)–H bond chlorination strategy of enaminones has been developed by using LiCl as a chlorinating reagent and K2S2O8 as an oxidant. This transformation provides a new and straightforward synthetic methodology to afford highly functionalized α-chlorinated enaminones with...

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Bibliographic Details
Published in:Journal of organic chemistry 2024-06, Vol.89 (12), p.8521-8530
Main Authors: Xie, Yunhua, Zhang, Zhilai, Zhang, Biao, He, Nengqin, Peng, Menglin, Song, Siyu, Wang, Baoqu, Yu, Fuchao
Format: Article
Language:English
Subjects:
chlorination
organic chemistry
oxidants
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Summary:An oxidative free-radical C­(sp2)–H bond chlorination strategy of enaminones has been developed by using LiCl as a chlorinating reagent and K2S2O8 as an oxidant. This transformation provides a new and straightforward synthetic methodology to afford highly functionalized α-chlorinated enaminones with a Z-configuration in good to excellent yields.
ISSN:0022-3263
1520-6904
1520-6904
DOI:10.1021/acs.joc.4c00456