Elevated serum 25-hydroxyvitamin D: a potential indicator of remission in Takayasu arteritis patients with normal ESR and CRP levels

• Published in: Clinical rheumatology 2024-06, Vol.43 (6), p.1979-1987
• Main Authors: Liao, Hua, Du, Juan, Li, Fengjuan, Yang, Shiyu, Qi, Guanming, Pan, Lili
• Format: Article
• Language: English
• Subjects: 25-Hydroxyvitamin D; Adolescent; Adult; Arteritis; Biomarkers - blood; Blood Sedimentation; blood serum; C-Reactive Protein - analysis; C-Reactive Protein - metabolism; Female; Humans; Male; Medicine; Medicine & Public Health; Middle Aged; Original Article; Remission; Remission (Medicine); Remission Induction; Retrospective Studies; Rheumatology; Severity of Illness Index; Takayasu Arteritis - blood; Takayasu Arteritis - drug therapy; Takayasu's disease; therapeutics; Vitamin D - analogs & derivatives; Vitamin D - blood; Young Adult
• ISSN: 0770-3198; 1434-9949; 1434-9949
• DOI: 10.1007/s10067-024-06957-w

Objective The goal of the present study was to investigate the correlation between serum 25-hydroxyvitamin D [25(OH)D] levels and disease remission in Takayasu arteritis (TAK) patients. Methods This retrospective study included 59 patients in the study group and 80 patients in the validation cohort with TAK. After 6 months of therapy, patients were re-evaluated, and serum 25(OH)D levels were compared before and after treatment. Correlations between changes in 25(OH)D levels and changes in disease activity scores (NIH, ITAS2010, ITAS.A) were analyzed. Additionally, a predictive cut-off value for disease remission was determined. Results After 6 months of therapy, serum 25(OH)D levels in TAK patients significantly increased compared to baseline [(18.33 ± 7.25)µg/L vs (11.77 ± 4.14) µg/L] ( P