Caries-Prone Primary Teeth: A Hidden Reason and Prophylactic Treatment in the Viewpoint of Materials Science

Dental caries, the most prevalent chronic disease across all age groups, has a high prevalence, particularly among children. However, there is no specific and effective treatment for the prevention of caries in primary teeth (Pr.T.), which stems from a lack of knowledge regarding the basic nature of...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2024-08, Vol.16 (32), p.41881-41891
Main Authors: Shen, Luxuan, Sun, Fan, Wang, Yu, Liu, Yang, Xin, Qiangwei, Zhu, Zhongpeng, Zhang, Hongbo, Xu, Xinyuan, Ding, Chunmei, Zheng, Liwei, Li, Jianshu
Format: Article
Language:English
Subjects:
adhesion
bacterial adhesion
Biological and Medical Applications of Materials and Interfaces
chronic diseases
dental caries
disease prevention
enamel
energy
hydrophilicity
hydroxyapatite
mineralization
oral hygiene
simulation models
Streptococcus mutans
Streptococcus sanguinis
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Summary:Dental caries, the most prevalent chronic disease across all age groups, has a high prevalence, particularly among children. However, there is no specific and effective treatment for the prevention of caries in primary teeth (Pr.T.), which stems from a lack of knowledge regarding the basic nature of the tooth surface. Herein, we observed that the adhesion energies of the caries-related bacteria Streptococcus mutans and Streptococcus sanguinis to Pr.T were approximately 10 and 5.5 times higher than those to permanent teeth (Pe.T). A lower degree of mineralization and more hydrophilic characteristics of the Pr.T enamel account for this discrepancy. Accordingly, we proposed that the on-target modification of both hydroxyapatite and organic components on Pr.T by dual modification would render a sufficient hydration layer. This resulted in an approximately 11-time decrease in bacterial adhesion energy after treatment. In contrast, a single hydroxyapatite modification on Pe.T and young permanent teeth (Y.Pe.T) was sufficient to achieve a similar effect. Theoretical simulation further verified the rationality of the approach. Our findings may help understand the reason for Pr.T being caries-prone and provide references for treatment using resin restorations. This strategy offers valuable insights into daily oral hygiene and dental prophylactic treatment in children.
ISSN:1944-8244
1944-8252
1944-8252
DOI:10.1021/acsami.4c07388