Piracetam reduces oxidative stress and mitochondrial function impairment in an in vitro model of vascular dementia

Vascular dementia (VaD) is the most common cause of dementia in older adults. Due to the lack of effective treatment options, there is an urgent need to find an effective pharmaceutical compound to combat VaD. Piracetam has been reported to improve impaired cognitive function in a variety of conditi...

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Bibliographic Details
Published in:Experimental brain research 2024-08, Vol.242 (8), p.1841-1850
Main Authors: Liu, Juan, Yang, Na, Wang, Xiaomeng, Wang, Wen
Format: Article
Language:English
Subjects:
1-Phosphatidylinositol 3-kinase
AKT protein
Animal models
Biomedical and Life Sciences
Biomedicine
brain
cognition
Cognitive ability
Dementia
Dementia disorders
drugs
humans
Mitochondria
Neurology
Neurosciences
Oxidative stress
Piracetam
Research Article
TOR protein
Vascular dementia
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Summary:Vascular dementia (VaD) is the most common cause of dementia in older adults. Due to the lack of effective treatment options, there is an urgent need to find an effective pharmaceutical compound to combat VaD. Piracetam has been reported to improve impaired cognitive function in a variety of conditions in both human and animal models. However, the role and mechanism of Piracetam in VaD remain unclear. Therefore this study aimed to elucidate the effect of Piracetam on a cellular model of VaD in vitro. We found that Piracetam enhanced the growth of OGD-stimulated SH-SY5Y cells. In addition, Piracetam inhibited the oxidative stress of OGD-stimulated SH-SY5Y cells. Further, Piracetam improved mitochondrial function of OGD-stimulated SH-SY5Y cells. Mechanistically, Piracetam inhibited the PI3K/Akt/mTOR pathway in OGD-stimulated SH-SY5Y cells. Collectively, Piracetam improved oxidative stress and mitochondrial dysfunction of OGD-stimulated SH-SY5Y cells through PI3K/Akt/mTOR axis. Hence, Piracetam has the potential to serve as a promising drug of VaD. Graphical abstract
ISSN:0014-4819
1432-1106
DOI:10.1007/s00221-024-06868-x