Wnt/β-catenin signaling pathway-a versatile player in apoptosis and autophagy

• Published in: Biochimie 2023-08, Vol.211, p.57-67
• Main Authors: Ma, Qinmei, Yu, Jialin, Zhang, Xu, Wu, Xiaoling, Deng, Guangcun
• Format: Article
• Language: English
• Subjects: Apoptosis; Autophagy; Autophagy - physiology; beta Catenin - metabolism; Cell Differentiation; Cell Proliferation; Crosstalk; homeostasis; Wnt Signaling Pathway; Wnt/β-catenin signaling
• ISSN: 0300-9084; 1638-6183
• DOI: 10.1016/j.biochi.2023.03.001

The Wnt/β-catenin signaling pathway is a highly conserved pathway that is involved in cell development, proliferation, differentiation, apoptosis and autophagy. Among these processes, apoptosis and autophagy occur physiologically during host defense and the maintenance of intracellular homeostasis. Mounting evidence suggests that the crosstalk between Wnt/β-catenin-regulated apoptosis and autophagy has broad functional significance in various diseases. Herein, we summarize the recent studies in understanding the role of the Wnt/β-catenin signaling pathway in apoptosis and autophagy, and draw the following conclusions: a) For apoptosis, the regulation of Wnt/β-catenin is generally positive. However, a small amount of evidence indicates the presence of a negatively regulated relationship between Wnt/β-catenin and apoptosis; b) Wnt/β-catenin influences the occurrence and development of autophagy by regulating autophagy-related factors, and these factors in turn affect Wnt/β-catenin pathway; c) Wnt/β-catenin always balances the molecular damage caused by the crosstalk between autophagy and apoptosis in a compensatory manner. Understanding the specific role of the Wnt/β-catenin signaling pathway during different stages of autophagy and apoptosis may provide new insights into the progression of related diseases regulated by the Wnt/β-catenin signaling pathway. •In the overwhelming majority of the cases, apoptosis is positively regulated by Wnt/β-catenin.•Wnt/β-catenin influences the occurrence and development of autophagy by regulating autophagy-related factors, and these factors in turn affect Wnt/β-catenin pathway.•Wnt/β-catenin balances the molecular damage caused by the crosstalk between autophagy and apoptosis in a compensatory manner.