Metabolic and hormonal profiling in polycystic ovarian syndrome: insights into INSR gene variations

Background Polycystic Ovary Syndrome (PCOS) is a hormonal disorder characterized by irregular periods, excess androgen levels, and polycystic ovaries, affecting many women of reproductive age. Methods and Results This study employed statistical and molecular analyses to compare hormone and metabolic...

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Bibliographic Details
Published in:Molecular biology reports 2024-12, Vol.51 (1), p.989-989, Article 989
Main Authors: Rasheed, Rezhna A., Rasheed, Poila H., Ali, Ayad M.
Format: Article
Language:English
Subjects:
Adult
Age differences
Amino acid sequence
amino acids
androgens
Animal Anatomy
Animal Biochemistry
Antigens, CD - genetics
Biomedical and Life Sciences
Case-Control Studies
Correlation analysis
Diabetes
Diabetes mellitus
Female
genes
Genetic Variation - genetics
Glycated Hemoglobin - metabolism
glycemic control
Histology
Humans
Insulin
Insulin - blood
Insulin - metabolism
Life Sciences
Low density lipoprotein
Luteinizing hormone
Metabolism
Morphology
Original Article
Ovaries
patients
Polycystic ovary syndrome
Polycystic Ovary Syndrome - genetics
Polycystic Ovary Syndrome - metabolism
Progesterone
Receptor, Insulin - genetics
Statistical analysis
Vitamin D
Vitamin D - blood
Vitamin D - metabolism
Young Adult
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Summary:Background Polycystic Ovary Syndrome (PCOS) is a hormonal disorder characterized by irregular periods, excess androgen levels, and polycystic ovaries, affecting many women of reproductive age. Methods and Results This study employed statistical and molecular analyses to compare hormone and metabolic markers between PCOS patients and controls. Sanger sequencing identified two INSR gene variants linked to high insulin and pre-diabetic conditions. Statistically, no significant age differences were detected ( p  = 0.492) between the overall PCOS patient pool and controls. However, a substantial variation in Vitamin D levels was observed within PCOS patients compared to controls ( p  = 0.0006), suggesting an association with PCOS. Correlations between Vitamin D and insulin, as well as HbA1c levels (R 2  = 0.141 and 0.143, respectively), suggest Vitamin D’s potential impact on glycemic control. Significant differences were found in HbA1c ( p  
ISSN:0301-4851
1573-4978
1573-4978
DOI:10.1007/s11033-024-09924-5