Collagen and collagenases in mare’s endometrium with endometrosis

Equine endometrosis is a degenerative and predominantly fibrotic condition resulting from progressive and irreversible multifactorial causes that influence the endometrium of mare. Tissue remodeling in the equine endometrium occurs as part of the pathogenesis of endometrosis, a process characterized...

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Published in:Theriogenology 2024-12, Vol.230, p.28-36
Main Authors: Centeno, Luiz Augusto M., Bastos, Henrique B.A., Bueno, Verônica L.C., Trentin, Janislene M., Fiorenza, MarianiF, Panziera, Welden, Winter, Gustavo H.Z., Kretzmann, Nelson A., Fiala-Rechsteiner, Sandra, Mattos, Rodrigo C., Rubin, Mara I.B.
Format: Article
Language:English
Subjects:
animal reproduction
Animals
collagen
Collagen - genetics
Collagen - metabolism
collagenase
Collagenases - metabolism
Endometriosis - genetics
Endometriosis - metabolism
Endometriosis - pathology
Endometriosis - veterinary
Endometrium
Endometrium - metabolism
Endometrium - pathology
Endometrosis
extracellular matrix
Female
Fibrosis
Fibrosis - veterinary
Gene expression
Gene Expression Regulation
Horse Diseases - genetics
Horse Diseases - metabolism
Horses
Mare
mares
pathogenesis
Picrosirius red
prognosis
Tissue Inhibitor of Metalloproteinase-2 - genetics
Tissue Inhibitor of Metalloproteinase-2 - metabolism
tumor necrosis factors
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Summary:Equine endometrosis is a degenerative and predominantly fibrotic condition resulting from progressive and irreversible multifactorial causes that influence the endometrium of mare. Tissue remodeling in the equine endometrium occurs as part of the pathogenesis of endometrosis, a process characterized by a shift in extracellular matrix (ECM) components. The relationship between matrix metalloproteinases and their specific inhibitors is crucial for the remodeling process. Collagen play a significant role in maintaining a healthy uterus and may promote fibrotic processes. The aim of this study was to quantify endometrial collagen deposition using picrosirius 25 red (PSR) staining, and to evaluate gene expression of collagen type 2 (COL-2) and 3 (COL-3), matrix metalloproteinases 1 (MMP-1) and 2 (MMP-2), their tissue inhibitor (TIMP-2), and tumor necrosis factor (TNF-α) in the endometrium of mares with different grades of fibrosis. The samples (n = 34) were classified into three categories based on the frequency and distribution of fibrosis-related changes in the endometrium: Category I (healthy endometrium, n = 12), Category II (moderate fibrosis, n = 12), and Category III (severe fibrosis, n = 10). Collagen quantification demonstrate a substantial proportional increase (P 
ISSN:0093-691X
1879-3231
1879-3231
DOI:10.1016/j.theriogenology.2024.08.031