Engineered upconversion nanocarriers for synergistic breast cancer imaging and therapy: Current state of art

Breast cancer is the most common type of cancer in women and is the second leading cause of cancer-related deaths worldwide. Early diagnosis and effective therapeutic interventions are critical determinants that can improve survival and quality of life in breast cancer patients. Nanotheranostics are...

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Bibliographic Details
Published in:Journal of controlled release 2022-12, Vol.352, p.652-672
Main Authors: Chintamaneni, Pavan Kumar, Nagasen, Dasari, Babu, Katta Chanti, Mourya, Atul, Madan, Jitender, Srinivasarao, Dadi A., Ramachandra, R.K., Santhoshi, P. Madhuri, Pindiprolu, Sai Kiran S.S.
Format: Article
Language:English
Subjects:
Bioimaging
Breast cancer
breast neoplasms
Breast Neoplasms - diagnostic imaging
Breast Neoplasms - therapy
cancer therapy
Drug delivery
drugs
early diagnosis
Female
gene transfer
Humans
Infrared Rays
luminescence
nanocarriers
nanoparticles
Nanoparticles - therapeutic use
Photochemotherapy
Photodynamic therapy
Photothermal therapy
photothermotherapy
Quality of Life
ultraviolet radiation
Upconversion nanoparticles
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Summary:Breast cancer is the most common type of cancer in women and is the second leading cause of cancer-related deaths worldwide. Early diagnosis and effective therapeutic interventions are critical determinants that can improve survival and quality of life in breast cancer patients. Nanotheranostics are emerging interventions that offer the dual benefit of in vivo diagnosis and therapeutics through a single nano-sized carrier. Rare earth metal-doped upconversion nanoparticles (UCNPs) with their ability to convert near-infrared light to visible light or UV light in vivo settings have gained special attraction due to their unique luminescence and tumor-targeting properties. In this review, we have discussed applications of UCNPs in drug and gene delivery, photothermal therapy (PTT), photodynamic therapy (PDT) and tumor targeting in breast cancer. Further, present challenges and future opportunities for UCNPs in breast cancer treatment have also been mentioned. [Display omitted]
ISSN:0168-3659
1873-4995
DOI:10.1016/j.jconrel.2022.10.056