BEX2 is poor prognostic factor and required for cancer stemness in gastric cancer

Gastric cancer is the fifth most common malignancy worldwide. However, targeted therapy for advanced gastric cancer is still limited. Here, we report BEX2 (Brain expressed X-linked 2) as a poor prognostic factor in two gastric cancer cohorts. BEX2 expression was increased in spheroid cells, and its...

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Published in:Biochemical and biophysical research communications 2023-05, Vol.655, p.59-67
Main Authors: Yasumoto, Akihiro, Fujimori, Haruna, Mochizuki, Mai, Shibuya-Takahashi, Rie, Nakamura-Shima, Mao, Shindo, Norihisa, Yamaguchi, Kazunori, Fukushi, Daisuke, Wakui, Yuta, Sugai, Takahiro, Iwai, Wataru, Abue, Makoto, Sato, Ikuro, Satoh, Kennichi, Katayose, Yu, Yasuda, Jun, Shibata, Chikashi, Tamai, Keiichi
Format: Article
Language:English
Subjects:
BEX2
brain
Cell Line, Tumor
CHRNB2
cisplatin
Gastric cancer
genes
Humans
Nerve Tissue Proteins - metabolism
Oncogenes
Prognosis
stomach neoplasms
Stomach Neoplasms - diagnosis
Stomach Neoplasms - genetics
therapeutics
transcription (genetics)
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Summary:Gastric cancer is the fifth most common malignancy worldwide. However, targeted therapy for advanced gastric cancer is still limited. Here, we report BEX2 (Brain expressed X-linked 2) as a poor prognostic factor in two gastric cancer cohorts. BEX2 expression was increased in spheroid cells, and its knockdown decreased aldefluor activity and cisplatin resistance. BEX2 was found to upregulate CHRNB2 (Cholinergic Receptor Nicotinic Beta 2 Subunit) expression, a cancer stemness-related gene, in a transcriptional manner, and the knockdown of which also decreases aldefluor activity. Collectively, these data are suggestive of the role of BEX2 in the malignant process of gastric cancer, and as a promising therapeutic target. •BEX2 (Brain expressed X-linked 2) is a new prognostic marker for gastric cancer.•BEX2 enhances cancer stem cell-related phenotypes.•BEX2 increases CHRNB2 transcript, a cancer stem cell-related gene.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2023.03.025