Stable Co(II)-based coordination polymer as fluorescence sensor for the discriminative sensing of biomarker methylmalonic acid

• Published in: Talanta (Oxford) 2023-12, Vol.265, p.124803-124803, Article 124803
• Main Authors: Luo, Rong, Xu, Cun-Gang, Zhang, Dong-Mei, Wang, Lu-Lu, Wu, Rui-Xue, Chen, Guo-Bo, Lu, Peng, Fan, Yu-Hua, Shao, Feng
• Format: Article
• Language: English
• Subjects: Biomarker; biomarkers; butanes; carbon dioxide; Coordination polymer; coordination polymers; detection limit; fluorescence; Fluorescent sensor; Methylmalonic acid; pyridines; topology; urine; X-ray diffraction
• ISSN: 0039-9140; 1873-3573
• DOI: 10.1016/j.talanta.2023.124803

Three novel Co-based coordination polymers including {[Co(L)(μ3-O)1/3]2}n (1), {[Co(L)(bimb)]}n (2) and {[Co(L)(bimmb)1/2]}n (3) (H2L = 2,6-di(4-carboxylphenyl)-4-(4-(triazol-1-ylphenyl))pyridine), bimb = 1,4-bis(lmidazol) butane, bimmb = 1,4-bis(imidazole-1-ylmethyl)benzene) were successfully prepared under solvothermal conditions and characterized. Single-crystal X-ray diffraction analyses revealed that 1 possesses a 3D architecture composed of a trinuclear cluster [Co3N3(CO2)6(μ3-O)], 2 exhibits a 2D new topological framework with the point symbol (84·122)(8)2, whereas 3 shows a unique six-fold interpenetrated 3D framework with a (63·82·10)2(63)2(8) topology. Impressively, all of them can function as a highly selective and sensitive fluorescent sensor for the biomarker methylmalonic acid (MMA) via fluorescence quenching. The low detection limit, reusability and high anti-interference performance together make 1–3 become promising sensors for the practical detection of MMA. Furthermore, the successful application of MMA detection in urine sample was demonstrated, which may be a potential candidate for the further development of clinical diagnostic tools. Three stable poly-dimensional Co-based coordination polymers give excellent application prospects as highly selective and sensitive sensing materials for the clinical biomarker methylmalonic acid of functional vitamin B12 status via fluorescence turn-off effect. [Display omitted] •Three Co-based coordination polymers (1–3) with different polydimensional architectures were synthesized.•1–3 exhibit fluorescent quenching behavior on clinical biomarker MMA of functional vitamin B12 status.•Detection mechanism of MMA of 1‒3 is investigated in detail by combined with density functional theory and a variety of other analytical methods.•1–3 achieved detection in simulated real-sample with satisfactory results.