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Effectiveness of the ten- and thirteen-valent pneumococcal conjugate vaccines to prevent serotype 19A invasive pneumococcal disease in Quebec, Canada. A Canadian immunization research network (CIRN) study
In the province of Quebec, Canada, a 2 + 1 dose pneumococcal conjugate vaccine (PCV) program for children was implemented in 2004. PCV7, PCV10, PCV13 and a mixed PCV10/PCV13 schedule were sequentially used without catch-up. The effectiveness of vaccination schedules to prevent serotype 19A invasive...
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Published in: | Vaccine 2024-12, Vol.42 (26), p.126379, Article 126379 |
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creator | Deceuninck, Geneviève Brousseau, Nicholas Lefebvre, Brigitte Quach, Caroline Tapiero, Bruce Bui, Yen-Giang Desjardins, Michael De Wals, Philippe |
description | In the province of Quebec, Canada, a 2 + 1 dose pneumococcal conjugate vaccine (PCV) program for children was implemented in 2004. PCV7, PCV10, PCV13 and a mixed PCV10/PCV13 schedule were sequentially used without catch-up. The effectiveness of vaccination schedules to prevent serotype 19A invasive pneumococcal disease (IPD) in |
doi_str_mv | 10.1016/j.vaccine.2024.126379 |
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Adjusted vaccine effectiveness (VEa) for ≥1 dose was 57 % [95 %CI: −1 %,82 %] for PCV10 and 62 % [16 %,83 %] for PCV13. VEa for 3 doses was 69 % [17 %,88 %] for PCV10, 76 % [39 %,90 %] for PCV13 and 86 % [64 %,95 %] for the 2PCV10 + 1PCV13 schedule. Protection provided by the PCV10-only schedule tended to be of lower magnitude compared to the two other schedules. The mixed PCV10 + PCV13 schedule showed a protection against 19A IPD at least comparable to that of 3 PCV-13 doses.</description><identifier>ISSN: 0264-410X</identifier><identifier>ISSN: 1873-2518</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2024.126379</identifier><identifier>PMID: 39332237</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Age ; Antigens ; Child, Preschool ; Children ; Conjugates ; Effectiveness ; Female ; Humans ; Immunization ; Immunization Programs ; Immunization Schedule ; Infant ; Invasive pneumococcal disease ; Laboratories ; Male ; Pneumococcal conjugated vaccine ; Pneumococcal Infections - epidemiology ; Pneumococcal Infections - immunology ; Pneumococcal Infections - prevention & control ; Pneumococcal Vaccines - administration & dosage ; Pneumococcal Vaccines - immunology ; Public health ; Quebec ; Quebec - epidemiology ; Schedules ; Serogroup ; Serotype-19A ; Streptococcus pneumoniae ; Streptococcus pneumoniae - classification ; Streptococcus pneumoniae - immunology ; Transplants & implants ; vaccination ; Vaccination - methods ; Vaccine effectiveness ; Vaccine Efficacy ; Vaccines ; Vaccines, Conjugate - administration & dosage ; Vaccines, Conjugate - immunology</subject><ispartof>Vaccine, 2024-12, Vol.42 (26), p.126379, Article 126379</ispartof><rights>2024 The Authors</rights><rights>Copyright © 2024 The Authors. 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The Authors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c304t-4fc11548e16f919cc422939be3756f0b0f245eb697606cf899e0088679208a7d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39332237$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Deceuninck, Geneviève</creatorcontrib><creatorcontrib>Brousseau, Nicholas</creatorcontrib><creatorcontrib>Lefebvre, Brigitte</creatorcontrib><creatorcontrib>Quach, Caroline</creatorcontrib><creatorcontrib>Tapiero, Bruce</creatorcontrib><creatorcontrib>Bui, Yen-Giang</creatorcontrib><creatorcontrib>Desjardins, Michael</creatorcontrib><creatorcontrib>De Wals, Philippe</creatorcontrib><title>Effectiveness of the ten- and thirteen-valent pneumococcal conjugate vaccines to prevent serotype 19A invasive pneumococcal disease in Quebec, Canada. A Canadian immunization research network (CIRN) study</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>In the province of Quebec, Canada, a 2 + 1 dose pneumococcal conjugate vaccine (PCV) program for children was implemented in 2004. PCV7, PCV10, PCV13 and a mixed PCV10/PCV13 schedule were sequentially used without catch-up. The effectiveness of vaccination schedules to prevent serotype 19A invasive pneumococcal disease (IPD) in <5-year-old children was estimated by the indirect cohort method during 2009–2023. A total of 248 19A IPD cases and 457 IPD controls were included in the analysis. Adjusted vaccine effectiveness (VEa) for ≥1 dose was 57 % [95 %CI: −1 %,82 %] for PCV10 and 62 % [16 %,83 %] for PCV13. VEa for 3 doses was 69 % [17 %,88 %] for PCV10, 76 % [39 %,90 %] for PCV13 and 86 % [64 %,95 %] for the 2PCV10 + 1PCV13 schedule. Protection provided by the PCV10-only schedule tended to be of lower magnitude compared to the two other schedules. 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VEa for 3 doses was 69 % [17 %,88 %] for PCV10, 76 % [39 %,90 %] for PCV13 and 86 % [64 %,95 %] for the 2PCV10 + 1PCV13 schedule. Protection provided by the PCV10-only schedule tended to be of lower magnitude compared to the two other schedules. The mixed PCV10 + PCV13 schedule showed a protection against 19A IPD at least comparable to that of 3 PCV-13 doses.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>39332237</pmid><doi>10.1016/j.vaccine.2024.126379</doi><oa>free_for_read</oa></addata></record> |
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subjects | Age Antigens Child, Preschool Children Conjugates Effectiveness Female Humans Immunization Immunization Programs Immunization Schedule Infant Invasive pneumococcal disease Laboratories Male Pneumococcal conjugated vaccine Pneumococcal Infections - epidemiology Pneumococcal Infections - immunology Pneumococcal Infections - prevention & control Pneumococcal Vaccines - administration & dosage Pneumococcal Vaccines - immunology Public health Quebec Quebec - epidemiology Schedules Serogroup Serotype-19A Streptococcus pneumoniae Streptococcus pneumoniae - classification Streptococcus pneumoniae - immunology Transplants & implants vaccination Vaccination - methods Vaccine effectiveness Vaccine Efficacy Vaccines Vaccines, Conjugate - administration & dosage Vaccines, Conjugate - immunology |
title | Effectiveness of the ten- and thirteen-valent pneumococcal conjugate vaccines to prevent serotype 19A invasive pneumococcal disease in Quebec, Canada. A Canadian immunization research network (CIRN) study |
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