Disseminated paracoccidioidomycosis in a captive western black-handed tamarin (Saguinus niger)

Paracoccidioidomycosis (PCM) is an endemic fungal disease that occurs in Latin America and primarily affects humans. The disease has been rarely documented in non-human primates. This report details a disseminated and fatal case of PCM caused by Paracoccidioides brasiliensis in a western black-hande...

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Bibliographic Details
Published in:Journal of comparative pathology 2024-10, Vol.214, p.1-6
Main Authors: de Oliveira, Isabelle D., Ferreira-Machado, Eduardo, Garcia, Jamile M., Simões, Sarah R.J.S., Figueiredo, Ketlyn B., Ressio, Rodrigo A., da Costa, André L.M., Matos, Flora N., Gonzaga, Cássia R.R., Leandro, Shamira S., de Medeiros, Marina A., Teixeira, Rodrigo H.F., Martins, Mariana C., Takahashi, Juliana P.F., de Araújo, Leonardo J.T., de Azevedo Fernandes, Natália C.C., Guerra, Juliana M.
Format: Article
Language:English
Subjects:
adrenal glands
animal
Animals
epididymis
fungal disease
heart
histopathology
humans
immunohistochemistry
inflammation
Latin America
liver
lymph
Male
Monkey Diseases - microbiology
Monkey Diseases - pathology
mycoses
Paracoccidioides
Paracoccidioides brasiliensis
paracoccidioidomycosis
Paracoccidioidomycosis - veterinary
primates
Saguinus
spleen
testes
yeasts
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Summary:Paracoccidioidomycosis (PCM) is an endemic fungal disease that occurs in Latin America and primarily affects humans. The disease has been rarely documented in non-human primates. This report details a disseminated and fatal case of PCM caused by Paracoccidioides brasiliensis in a western black-handed tamarin (Saguinus niger) under human care. Histopathological examination revealed extensive pyogranulomatous inflammation in the lungs, spleen, liver, lymph nodes, kidneys, epididymis, right testicle, heart, adrenal gland and intestines, associated with characteristic yeast forms consistent with Paracoccidioides spp and confirmed by immunohistochemistry. Molecular analysis indicated a high nucleotide similarity with P. brasiliensis sequences for both the 18S rRNA and gp43 genes. This naturally occurring infection highlights the susceptibility of these animals to PCM and their role in ecoepidemiology warrants further investigation.
ISSN:0021-9975
1532-3129
1532-3129
DOI:10.1016/j.jcpa.2024.07.005