Polysaccharide-based chondroitin sulfate macromolecule loaded hydrogel/scaffolds in wound healing- A comprehensive review on possibilities, research gaps, and safety assessment

• Published in: International journal of biological macromolecules 2024-11, Vol.279 (Pt 3), p.135410, Article 135410
• Main Authors: Mantry, Shubhrajit, Behera, Ashutosh, Pradhan, Shaktiprasad, Mohanty, Lalatendu, Kumari, Ragni, Singh, Ankita, Yadav, Mahesh Kumar
• Format: Article
• Language: English
• Subjects: Chondroitin sulfate; health services; Hydrogel; hydrogels; Macromolecules; Polysaccharides; safety assessment; Scaffolds; tissue repair; toxicity; Wound healing
• ISSN: 0141-8130; 1879-0003; 1879-0003
• DOI: 10.1016/j.ijbiomac.2024.135410

Wound healing is an intricate multifactorial process that may alter the extent of scarring left by the wound. A substantial portion of the global population is impacted by non-healing wounds, imposing significant financial burdens on the healthcare system. The conventional dosage forms fail to improve the condition, especially in the presence of other morbidities. Thus, there is a pressing requirement for a type of wound dressing that can safeguard the wound site and facilitate skin regeneration, ultimately expediting the healing process. In this context, Chondroitin sulfate (CS), a sulfated glycosaminoglycan material, is capable of hydrating tissues and further promoting the healing. Thus, this comprehensive review article delves into the recent advancement of CS-based hydrogel/scaffolds for wound healing management. The article initially summarizes the various physicochemical characteristics and sources of CS, followed by a brief understanding of the importance of hydrogel and CS in tissue regeneration processes. This is the first instance of such a comprehensive summarization of CS-based hydrogel/scaffolds in wound healing, focusing more on the mechanistic wound healing process, furnishing the recent innovations and toxicity profile. This contemporary review provides a profound acquaintance of strategies for contemporary challenges and future direction in CS-based hydrogel/scaffolds for wound healing. [Display omitted] •Wound healing is an intricate multifactorial process involved healing stages.•Chondroitin sulfate (CS), an anionic sulfated polysaccharide-based macromolecule exhibited wound healing.•Chondroitin sulfate regulates cell behaviors and fates to facilitate wound healing.•Advancement and toxicity profile of CS-based hydrogel/scaffolds in chronic wound healing.