Bioinformatic Tools for Studying the Cellular Immune Response to SARS-CoV-2, Vaccine Efficacy, and Future Pandemics at the Global Population Level

Antigen recognition by human leukocyte antigen (HLA) restriction is critical for an adequate antiviral response in both natural infection and vaccination. However, the overwhelming polymorphism of HLA, with nearly 40,000 alleles identified, is an important limitation for the global analysis of cellu...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-12, Vol.25 (24), p.13477
Main Authors: López, Daniel, Zumárraga, Javier
Format: Article
Language:English
Subjects:
Algorithms
Amino acids
Antigens
B cells
Binding sites
Bioinformatics
China
Computational Biology - methods
COVID-19 - epidemiology
COVID-19 - immunology
COVID-19 - prevention & control
COVID-19 - virology
COVID-19 Vaccines - immunology
Cytokines
Endoplasmic reticulum
Epidemics
Genomes
Health aspects
Histocompatibility antigens
HLA Antigens - genetics
HLA Antigens - immunology
HLA histocompatibility antigens
Humans
Immune response
Immune system
Immunity, Cellular
Infection
Laboratories
Ligands
Lymphocytes
Mass spectrometry
Medical research
Medicine, Experimental
Mutation
Pandemics - prevention & control
Pathogens
Peptides
Polymorphism
Population
Proteins
Research methodology
SARS-CoV-2 - immunology
Scientific imaging
Severe acute respiratory syndrome coronavirus 2
T cell receptors
Vaccination
Vaccine Efficacy
Vaccines
Viral infections
Viruses
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Description
Summary:Antigen recognition by human leukocyte antigen (HLA) restriction is critical for an adequate antiviral response in both natural infection and vaccination. However, the overwhelming polymorphism of HLA, with nearly 40,000 alleles identified, is an important limitation for the global analysis of cellular immune responses and vaccine efficacy. In this narrative review, we included several immunoinformatics studies performed in our laboratory to circumvent this limitation. These analyses focused on studying the cellular immune responses restricted by the most common HLA alleles, and their role in vaccine efficacy. Computational studies validated experimentally, such as our laboratory has carried out, represent a useful, rapid, and cost-effective strategy to combat future pandemics.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms252413477