The RAGE Pathway in Skin Pathology Development: A Comprehensive Review of Its Role and Therapeutic Potential

The receptor for advanced glycation end-products (RAGE), a member of the immunoglobulin superfamily, is expressed in various cell types and mediates cellular responses to a wide range of ligands. The activation of RAGE triggers complex signaling pathways that drive inflammatory, oxidative, and proli...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-12, Vol.25 (24), p.13570
Main Authors: Radziszewski, Marcin, Galus, Ryszard, Łuszczyński, Krzysztof, Winiarski, Sebastian, Wąsowski, Dariusz, Malejczyk, Jacek, Włodarski, Paweł, Ścieżyńska, Aneta
Format: Article
Language:English
Subjects:
Animals
Atopic dermatitis
Chronic illnesses
Cytokines
Development and progression
Gene expression
Health aspects
Humans
Immunoglobulins
Inflammation
Kinases
Ligands
Metastasis
Pathogenesis
Peptides
Proteins
Psoriasis
Receptor for Advanced Glycation End Products - metabolism
Signal Transduction
Skin
Skin - metabolism
Skin - pathology
Skin cancer
Skin diseases
Skin Diseases - metabolism
Skin Diseases - pathology
Skin Diseases - therapy
Transcription factors
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Summary:The receptor for advanced glycation end-products (RAGE), a member of the immunoglobulin superfamily, is expressed in various cell types and mediates cellular responses to a wide range of ligands. The activation of RAGE triggers complex signaling pathways that drive inflammatory, oxidative, and proliferative responses, which are increasingly implicated in the pathogenesis of skin diseases. Despite its well-established roles in conditions such as diabetes, cancer, and chronic inflammation, the contribution of RAGE to skin pathologies remains underexplored. This review synthesizes current findings on RAGE's involvement in the pathophysiology of skin diseases, including conditions such as psoriasis, atopic dermatitis, and lichen planus, focusing on its roles in inflammatory signaling, tissue remodeling, and skin cancer progression. Additionally, it examines RAGE-modulating treatments investigated in dermatological contexts, highlighting their potential as therapeutic options. Given RAGE's significance in a variety of skin conditions, further research into its mediated pathways may uncover new opportunities for targeted interventions in skin-specific RAGE signaling.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms252413570