Isopimpinellin inhibits UVA-induced overproduction of MMPs via suppression of MAPK/AP-1 signaling in human dermal fibroblasts

Corydalis heterocarpa is an edible halophyte and an ingredient in traditional Korean medicine. In the present study, isopimpinellin (IPN), a bioactive coumarin, was isolated from the medicinal halophyte C. heterocarpa , and the effects of IPN against UVA-induced photoaging were investigated in human...

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Bibliographic Details
Published in:Food science and biotechnology 2024-12, Vol.33 (15), p.3579-3589
Main Authors: Oh, Jung Hwan, Karadeniz, Fatih, Seo, Youngwan, Kong, Chang-Suk
Format: Article
Language:English
Subjects:
Aging (artificial)
c-Fos protein
c-Jun protein
Chemistry
Chemistry and Materials Science
Chronic exposure
collagenase
Connective tissue diseases
Connective tissues
Corydalis
Coumarin
Fibroblasts
Food Science
Gelatinase B
Halophytes
humans
ingredients
Interstitial collagenase
Isopimpinellin
MAP kinase
Matrix metalloproteinase
Matrix metalloproteinases
Nutrition
Oriental traditional medicine
Phosphorylation
photoaging
protein content
Reactive oxygen species
Research Article
Skin diseases
Stromelysin 1
Transcription factors
Ultraviolet radiation
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Summary:Corydalis heterocarpa is an edible halophyte and an ingredient in traditional Korean medicine. In the present study, isopimpinellin (IPN), a bioactive coumarin, was isolated from the medicinal halophyte C. heterocarpa , and the effects of IPN against UVA-induced photoaging were investigated in human dermal fibroblasts. Photoaging is a skin disorder that manifests itself as premature skin aging due to chronic exposure to UV radiation. The symptoms of photoaging mainly arise from degraded skin connective tissue produced by overly expressed matrix metalloproteinases (MMPs). IPN treatment decreased the UVA-induced formation of reactive oxygen species and decreased MMP-1, MMP-3, and MMP-9 collagenases at the protein level. The UVA-mediated suppression of tissue inhibitors of MMP-1 and -2 was attenuated with IPN. The presence of 10 μM IPN inhibited the MAPK-mediated phosphorylation of c-Fos and c-Jun. In conclusion, the overall result of the current study indicated that IPN inhibited the UVA-induced overexpression of MMPs via blocking the MAPK/AP-1 pathway.
ISSN:1226-7708
2092-6456
2092-6456
DOI:10.1007/s10068-024-01611-2