Exploring quorum sensing for inducing bioactives overproduction in the dinoflagellate microalga Amphidinium carterae

The dinoflagellate Amphidinium carterae is a promising source of unique bioactive compounds with potential applications in diverse industries. Abiotic strategies for increasing bioactive cell quota have been preferred for cost-effectiveness, controllability, and existing knowledge. The supernatants...

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Bibliographic Details
Published in:Algal research (Amsterdam) 2024-10, Vol.83, p.103719, Article 103719
Main Authors: Kichouh-Aiadi, S., Gallardo-Rodríguez, J.J., López-Rosales, L., Cerón-García, M.C., García-Camacho, F., Sánchez-Mirón, A.
Format: Article
Language:English
Subjects:
Allelopathy
Amphidinium
Bioactive
bioactive compounds
biomass
Bioprocess
carotenoids
circular economy
cost effectiveness
culture media
hemolysis
Heterosigma akashiwo
industry
lipid content
metabolites
Microalga
microalgae
OSMAC
Pavlova
Pleurochrysis
Prymnesium parvum
Quorum sensing
wastes
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Summary:The dinoflagellate Amphidinium carterae is a promising source of unique bioactive compounds with potential applications in diverse industries. Abiotic strategies for increasing bioactive cell quota have been preferred for cost-effectiveness, controllability, and existing knowledge. The supernatants of Heterosigma akashiwo and Pavlova sp. enhanced haemolytic activity of A. carterae by 2.3 times and improved its final biomass by 10 % when added to the growth medium. Prymnesium parvum supernatant increased the total lipid content of A. carterae by 50 %, while Pleurochrysis roscoffensis supernatant boosted its total carotenoid content by 40 %. This study demonstrated a rapid screening strategy for evaluating growth responses and highlights the potential of using allelopathic strategies to enhance bioactive metabolite production. Utilizing supernatants for the formulation of growth media fosters a circular economy by repurposing resources, minimizing waste, and promoting sustainability in the microalgal biotechnological industry. [Display omitted] •38 microalgal supernatants were evaluated for stimulating A. carterae.•Quorum sensing allowed increasing total lipid and carotenoid content.•Evidence of amphidinols overproduction was found for many species.•Repurposing supernatants as a biostimulant enhances circularity.
ISSN:2211-9264
2211-9264
DOI:10.1016/j.algal.2024.103719