Exploring quorum sensing for inducing bioactives overproduction in the dinoflagellate microalga Amphidinium carterae

• Published in: Algal research (Amsterdam) 2024-10, Vol.83, p.103719, Article 103719
• Main Authors: Kichouh-Aiadi, S., Gallardo-Rodríguez, J.J., López-Rosales, L., Cerón-García, M.C., García-Camacho, F., Sánchez-Mirón, A.
• Format: Article
• Language: English
• Subjects: Allelopathy; Amphidinium; Bioactive; bioactive compounds; biomass; Bioprocess; carotenoids; circular economy; cost effectiveness; culture media; hemolysis; Heterosigma akashiwo; industry; lipid content; metabolites; Microalga; microalgae; OSMAC; Pavlova; Pleurochrysis; Prymnesium parvum; Quorum sensing; wastes
• ISSN: 2211-9264; 2211-9264
• DOI: 10.1016/j.algal.2024.103719

The dinoflagellate Amphidinium carterae is a promising source of unique bioactive compounds with potential applications in diverse industries. Abiotic strategies for increasing bioactive cell quota have been preferred for cost-effectiveness, controllability, and existing knowledge. The supernatants of Heterosigma akashiwo and Pavlova sp. enhanced haemolytic activity of A. carterae by 2.3 times and improved its final biomass by 10 % when added to the growth medium. Prymnesium parvum supernatant increased the total lipid content of A. carterae by 50 %, while Pleurochrysis roscoffensis supernatant boosted its total carotenoid content by 40 %. This study demonstrated a rapid screening strategy for evaluating growth responses and highlights the potential of using allelopathic strategies to enhance bioactive metabolite production. Utilizing supernatants for the formulation of growth media fosters a circular economy by repurposing resources, minimizing waste, and promoting sustainability in the microalgal biotechnological industry. [Display omitted] •38 microalgal supernatants were evaluated for stimulating A. carterae.•Quorum sensing allowed increasing total lipid and carotenoid content.•Evidence of amphidinols overproduction was found for many species.•Repurposing supernatants as a biostimulant enhances circularity.