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Stable Isotope Ratio Mass Spectrometry and Site-Specific Natural Isotope Fractionation-Nuclear Magnetic Resonance applications to discriminate between synthetic and natural analogs: A review
Consumers are nowadays increasingly demanding products containing molecules of natural origin, as they are considered healthier than the synthetic or semi-synthetic counterparts. The higher costs associated with the production of plant raw materials and/or the extraction and purification of these na...
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Published in: | TrAC, Trends in analytical chemistry (Regular ed.) Trends in analytical chemistry (Regular ed.), 2024-11, Vol.180, p.117966, Article 117966 |
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description | Consumers are nowadays increasingly demanding products containing molecules of natural origin, as they are considered healthier than the synthetic or semi-synthetic counterparts. The higher costs associated with the production of plant raw materials and/or the extraction and purification of these natural substances set the basis for possible counterfeiting, resulting in the addition of cheaper, chemically indistinguishable synthetic form. In this review, we will discuss the effectiveness of stable isotope ratio mass spectrometry and/or Site-Specific Natural Isotope Fractionation-Nuclear Magnetic Resonance for the discrimination between molecules of natural and synthetic origin belonging to the families of flavourings, essential oils, foodstuff, dietary supplements, drugs and steroids.
•The same compound can be obtained via natural, biotechnological, synthetic pathways.•Bulk and site-specific isotopic ratios can distinguish the origin of a compound.•Comprehensive list of sources on IRMS and SNIF-NMR on this topic reviewed in the paper.•Overview of best practices and advantages/disadvantages of IRMS and SNIF-NMR. |
doi_str_mv | 10.1016/j.trac.2024.117966 |
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•The same compound can be obtained via natural, biotechnological, synthetic pathways.•Bulk and site-specific isotopic ratios can distinguish the origin of a compound.•Comprehensive list of sources on IRMS and SNIF-NMR on this topic reviewed in the paper.•Overview of best practices and advantages/disadvantages of IRMS and SNIF-NMR.</description><identifier>ISSN: 0165-9936</identifier><identifier>DOI: 10.1016/j.trac.2024.117966</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>analytical chemistry ; Authentication ; foods ; IRMS ; magnetism ; mass spectrometry ; Natural ; SNIF-NMR ; stable isotopes ; Synthetic</subject><ispartof>TrAC, Trends in analytical chemistry (Regular ed.), 2024-11, Vol.180, p.117966, Article 117966</ispartof><rights>2024 The Authors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c284t-a4bc5cacf17fd1a850ef8e861628c704ea24f52bceee85e3020bff432e3df77c3</cites><orcidid>0000-0002-9880-9590</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27898,27899</link.rule.ids></links><search><creatorcontrib>Perini, M.</creatorcontrib><creatorcontrib>Pianezze, S.</creatorcontrib><creatorcontrib>Bontempo, L.</creatorcontrib><title>Stable Isotope Ratio Mass Spectrometry and Site-Specific Natural Isotope Fractionation-Nuclear Magnetic Resonance applications to discriminate between synthetic and natural analogs: A review</title><title>TrAC, Trends in analytical chemistry (Regular ed.)</title><description>Consumers are nowadays increasingly demanding products containing molecules of natural origin, as they are considered healthier than the synthetic or semi-synthetic counterparts. The higher costs associated with the production of plant raw materials and/or the extraction and purification of these natural substances set the basis for possible counterfeiting, resulting in the addition of cheaper, chemically indistinguishable synthetic form. In this review, we will discuss the effectiveness of stable isotope ratio mass spectrometry and/or Site-Specific Natural Isotope Fractionation-Nuclear Magnetic Resonance for the discrimination between molecules of natural and synthetic origin belonging to the families of flavourings, essential oils, foodstuff, dietary supplements, drugs and steroids.
•The same compound can be obtained via natural, biotechnological, synthetic pathways.•Bulk and site-specific isotopic ratios can distinguish the origin of a compound.•Comprehensive list of sources on IRMS and SNIF-NMR on this topic reviewed in the paper.•Overview of best practices and advantages/disadvantages of IRMS and SNIF-NMR.</description><subject>analytical chemistry</subject><subject>Authentication</subject><subject>foods</subject><subject>IRMS</subject><subject>magnetism</subject><subject>mass spectrometry</subject><subject>Natural</subject><subject>SNIF-NMR</subject><subject>stable isotopes</subject><subject>Synthetic</subject><issn>0165-9936</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kctKBDEQRbNQUEd_wFWWbnpM0s8RNyK-wAc4ug7V6Ypm6EnaJOMwP-e3mXbEpRAIpOrcm6pLyDFnU854dbqYRg9qKpgoppzXs6raIfupUGazWV7tkYMQFoyxirHZPvmaR2h7pHfBRTcgfYZoHH2AEOh8QBW9W2L0Gwq2o3MTMRtfjTaKPkJceej_yOtkmlg7CtjscaV6BJ-U3izG1P6MIdWsQgrD0Bv10xZodLQzQXmzNIlE2mJcI1oaNja-_4Cjs_31Agu9ewtn9IJ6_DS4PiS7GvqAR7_3hLxeX71c3mb3Tzd3lxf3mRJNETMoWlUqUJrXuuPQlAx1g03FK9GomhUIotClaBUiNiXmTLBW6yIXmHe6rlU-ISdb3cG7jxWGKJfp19j3YNGtgsx5WaRTpA1PiNi2Ku9C8KjlkKYDv5GcyTEguZBjQHIMSG4DStD5FsI0RBrMy6AMpm11xqcUZOfMf_g3BnCh8A</recordid><startdate>202411</startdate><enddate>202411</enddate><creator>Perini, M.</creator><creator>Pianezze, S.</creator><creator>Bontempo, L.</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0002-9880-9590</orcidid></search><sort><creationdate>202411</creationdate><title>Stable Isotope Ratio Mass Spectrometry and Site-Specific Natural Isotope Fractionation-Nuclear Magnetic Resonance applications to discriminate between synthetic and natural analogs: A review</title><author>Perini, M. ; Pianezze, S. ; Bontempo, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c284t-a4bc5cacf17fd1a850ef8e861628c704ea24f52bceee85e3020bff432e3df77c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>analytical chemistry</topic><topic>Authentication</topic><topic>foods</topic><topic>IRMS</topic><topic>magnetism</topic><topic>mass spectrometry</topic><topic>Natural</topic><topic>SNIF-NMR</topic><topic>stable isotopes</topic><topic>Synthetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perini, M.</creatorcontrib><creatorcontrib>Pianezze, S.</creatorcontrib><creatorcontrib>Bontempo, L.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>CrossRef</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>TrAC, Trends in analytical chemistry (Regular ed.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Perini, M.</au><au>Pianezze, S.</au><au>Bontempo, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stable Isotope Ratio Mass Spectrometry and Site-Specific Natural Isotope Fractionation-Nuclear Magnetic Resonance applications to discriminate between synthetic and natural analogs: A review</atitle><jtitle>TrAC, Trends in analytical chemistry (Regular ed.)</jtitle><date>2024-11</date><risdate>2024</risdate><volume>180</volume><spage>117966</spage><pages>117966-</pages><artnum>117966</artnum><issn>0165-9936</issn><abstract>Consumers are nowadays increasingly demanding products containing molecules of natural origin, as they are considered healthier than the synthetic or semi-synthetic counterparts. The higher costs associated with the production of plant raw materials and/or the extraction and purification of these natural substances set the basis for possible counterfeiting, resulting in the addition of cheaper, chemically indistinguishable synthetic form. In this review, we will discuss the effectiveness of stable isotope ratio mass spectrometry and/or Site-Specific Natural Isotope Fractionation-Nuclear Magnetic Resonance for the discrimination between molecules of natural and synthetic origin belonging to the families of flavourings, essential oils, foodstuff, dietary supplements, drugs and steroids.
•The same compound can be obtained via natural, biotechnological, synthetic pathways.•Bulk and site-specific isotopic ratios can distinguish the origin of a compound.•Comprehensive list of sources on IRMS and SNIF-NMR on this topic reviewed in the paper.•Overview of best practices and advantages/disadvantages of IRMS and SNIF-NMR.</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.trac.2024.117966</doi><orcidid>https://orcid.org/0000-0002-9880-9590</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | analytical chemistry Authentication foods IRMS magnetism mass spectrometry Natural SNIF-NMR stable isotopes Synthetic |
title | Stable Isotope Ratio Mass Spectrometry and Site-Specific Natural Isotope Fractionation-Nuclear Magnetic Resonance applications to discriminate between synthetic and natural analogs: A review |
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