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Immuno-pathogenesis study of local infectious bronchitis virus G1-1 lineage variant showed altered tissue tropism in experimental broiler chickens
Infectious bronchitis (IB) is an acute contagious disease of poultry caused by infectious bronchitis virus (IBV). This study investigated the immunopathogenesis and tissue tropism of an Indian IBV field isolate (IBV/Chicken/India/IVRI/Rajasthan/01/2023) in experimental broiler chickens. This isolate...
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| Published in: | Veterinary research communications 2024-12, Vol.48 (6), p.3683-3697 |
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| creator | Sharma, Megha Rahman, Faslu A. T. Sharma, Gaurav Dey, Sohini Chellappa, Madhan Mohan Sharma, Anshuk Dhama, Kuldeep Saikumar, G. Kumar, Asok M. |
| description | Infectious bronchitis (IB) is an acute contagious disease of poultry caused by infectious bronchitis virus (IBV). This study investigated the immunopathogenesis and tissue tropism of an Indian IBV field isolate (IBV/Chicken/India/IVRI/Rajasthan/01/2023) in experimental broiler chickens. This isolate belongs to the G1-1 lineage and is closely associated with the Mass genotype. 10
6.23
EID
50
/0.2 mL of the virus was administered intranasally and intraocularly to the IBV-challenge group, whereas uninoculated allantoic fluid was administered to the control group. Clinical signs, gross and histopathological lesions, immunohistochemistry (IHC), viral load, humoral responses, and the relative expression of immune response genes were evaluated at seven observation points. The infected group showed a significant reduction in weight gain from 3 dpi onwards, with clinical signs of varying severity from 3 to − 11 dpi. Gross lesions and microscopic changes were observed in the nasal turbinates, trachea, lungs, and kidneys, mainly representing epithelial degeneration and necrosis with mononuclear infiltrates. The caecal tonsils also showed microscopic lesions at 7–9 dpi. Absolute viral load estimation in the organs corroborated the lesion severity scores and IHC results. The expression of innate immune responses broadly demonstrated higher expression in the trachea and lungs of the IBV-infected group during the early phase of infection, whereas similar responses were observed in the kidneys and caecal tonsils during the later phases of infection. This study suggests that the given IBV isolate may cause significant production losses in broilers and exhibit tissue tropism for both respiratory and non-respiratory tissues, triggering varying innate and adaptive immune responses. |
| doi_str_mv | 10.1007/s11259-024-10525-7 |
| format | article |
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6.23
EID
50
/0.2 mL of the virus was administered intranasally and intraocularly to the IBV-challenge group, whereas uninoculated allantoic fluid was administered to the control group. Clinical signs, gross and histopathological lesions, immunohistochemistry (IHC), viral load, humoral responses, and the relative expression of immune response genes were evaluated at seven observation points. The infected group showed a significant reduction in weight gain from 3 dpi onwards, with clinical signs of varying severity from 3 to − 11 dpi. Gross lesions and microscopic changes were observed in the nasal turbinates, trachea, lungs, and kidneys, mainly representing epithelial degeneration and necrosis with mononuclear infiltrates. The caecal tonsils also showed microscopic lesions at 7–9 dpi. Absolute viral load estimation in the organs corroborated the lesion severity scores and IHC results. The expression of innate immune responses broadly demonstrated higher expression in the trachea and lungs of the IBV-infected group during the early phase of infection, whereas similar responses were observed in the kidneys and caecal tonsils during the later phases of infection. This study suggests that the given IBV isolate may cause significant production losses in broilers and exhibit tissue tropism for both respiratory and non-respiratory tissues, triggering varying innate and adaptive immune responses.</description><identifier>ISSN: 0165-7380</identifier><identifier>ISSN: 1573-7446</identifier><identifier>EISSN: 1573-7446</identifier><identifier>DOI: 10.1007/s11259-024-10525-7</identifier><identifier>PMID: 39222200</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Allantoic fluid ; Animals ; Biomedical and Life Sciences ; Bronchitis ; cecum ; chickens ; Chickens - virology ; Coronavirus Infections - immunology ; Coronavirus Infections - pathology ; Coronavirus Infections - veterinary ; Coronavirus Infections - virology ; epithelium ; genotype ; Genotypes ; histopathology ; immune response ; Immune response (humoral) ; Immunohistochemistry ; Immunopathogenesis ; India ; infectious bronchitis ; Infectious bronchitis virus ; Infectious bronchitis virus - genetics ; Infectious bronchitis virus - immunology ; Infectious bronchitis virus - pathogenicity ; Infectious bronchitis virus - physiology ; Innate immunity ; Kidneys ; Lesions ; Life Sciences ; Lungs ; necrosis ; Nose ; Poultry ; Poultry Diseases - immunology ; Poultry Diseases - pathology ; Poultry Diseases - virology ; tissue tropism ; Tonsil ; Trachea ; Tropism ; Veterinary Medicine/Veterinary Science ; viral load ; Viral Load - veterinary ; Viral Tropism ; Viruses ; weight gain ; Zoology</subject><ispartof>Veterinary research communications, 2024-12, Vol.48 (6), p.3683-3697</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Nature B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c289t-6426a26124b84b0172d16f1a1fe537cec62568abd4c653c9bf4aa17b5807d7103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39222200$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sharma, Megha</creatorcontrib><creatorcontrib>Rahman, Faslu A. T.</creatorcontrib><creatorcontrib>Sharma, Gaurav</creatorcontrib><creatorcontrib>Dey, Sohini</creatorcontrib><creatorcontrib>Chellappa, Madhan Mohan</creatorcontrib><creatorcontrib>Sharma, Anshuk</creatorcontrib><creatorcontrib>Dhama, Kuldeep</creatorcontrib><creatorcontrib>Saikumar, G.</creatorcontrib><creatorcontrib>Kumar, Asok M.</creatorcontrib><title>Immuno-pathogenesis study of local infectious bronchitis virus G1-1 lineage variant showed altered tissue tropism in experimental broiler chickens</title><title>Veterinary research communications</title><addtitle>Vet Res Commun</addtitle><addtitle>Vet Res Commun</addtitle><description>Infectious bronchitis (IB) is an acute contagious disease of poultry caused by infectious bronchitis virus (IBV). This study investigated the immunopathogenesis and tissue tropism of an Indian IBV field isolate (IBV/Chicken/India/IVRI/Rajasthan/01/2023) in experimental broiler chickens. This isolate belongs to the G1-1 lineage and is closely associated with the Mass genotype. 10
6.23
EID
50
/0.2 mL of the virus was administered intranasally and intraocularly to the IBV-challenge group, whereas uninoculated allantoic fluid was administered to the control group. Clinical signs, gross and histopathological lesions, immunohistochemistry (IHC), viral load, humoral responses, and the relative expression of immune response genes were evaluated at seven observation points. The infected group showed a significant reduction in weight gain from 3 dpi onwards, with clinical signs of varying severity from 3 to − 11 dpi. Gross lesions and microscopic changes were observed in the nasal turbinates, trachea, lungs, and kidneys, mainly representing epithelial degeneration and necrosis with mononuclear infiltrates. The caecal tonsils also showed microscopic lesions at 7–9 dpi. Absolute viral load estimation in the organs corroborated the lesion severity scores and IHC results. The expression of innate immune responses broadly demonstrated higher expression in the trachea and lungs of the IBV-infected group during the early phase of infection, whereas similar responses were observed in the kidneys and caecal tonsils during the later phases of infection. This study suggests that the given IBV isolate may cause significant production losses in broilers and exhibit tissue tropism for both respiratory and non-respiratory tissues, triggering varying innate and adaptive immune responses.</description><subject>Allantoic fluid</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Bronchitis</subject><subject>cecum</subject><subject>chickens</subject><subject>Chickens - virology</subject><subject>Coronavirus Infections - immunology</subject><subject>Coronavirus Infections - pathology</subject><subject>Coronavirus Infections - veterinary</subject><subject>Coronavirus Infections - virology</subject><subject>epithelium</subject><subject>genotype</subject><subject>Genotypes</subject><subject>histopathology</subject><subject>immune response</subject><subject>Immune response (humoral)</subject><subject>Immunohistochemistry</subject><subject>Immunopathogenesis</subject><subject>India</subject><subject>infectious bronchitis</subject><subject>Infectious bronchitis virus</subject><subject>Infectious bronchitis virus - genetics</subject><subject>Infectious bronchitis virus - immunology</subject><subject>Infectious bronchitis virus - pathogenicity</subject><subject>Infectious bronchitis virus - physiology</subject><subject>Innate immunity</subject><subject>Kidneys</subject><subject>Lesions</subject><subject>Life Sciences</subject><subject>Lungs</subject><subject>necrosis</subject><subject>Nose</subject><subject>Poultry</subject><subject>Poultry Diseases - immunology</subject><subject>Poultry Diseases - pathology</subject><subject>Poultry Diseases - virology</subject><subject>tissue tropism</subject><subject>Tonsil</subject><subject>Trachea</subject><subject>Tropism</subject><subject>Veterinary Medicine/Veterinary Science</subject><subject>viral load</subject><subject>Viral Load - veterinary</subject><subject>Viral Tropism</subject><subject>Viruses</subject><subject>weight gain</subject><subject>Zoology</subject><issn>0165-7380</issn><issn>1573-7446</issn><issn>1573-7446</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFkc1u1TAQRi0EopfCC7BAltiwCXj8myxRBaVSJTawjhxncq9LYgfbaelr8MS43AISC_BmpPHxGY0_Qp4Dew2MmTcZgKuuYVw2wBRXjXlAdqCMaIyU-iHZMdC1KVp2Qp7kfMUY61omHpMT0fF6GNuR7xfLsoXYrLYc4h4DZp9pLtt4S-NE5-jsTH2Y0BUft0yHFIM7-FKha59q4xwaoLMPaPdIr23yNhSaD_EGR2rngqnWSucNaUlx9XmpOorfVkx-wVCqvjr9jIlWr_uCIT8ljyY7Z3x2X0_J5_fvPp19aC4_nl-cvb1sHG-70mjJteUauBxaOTAwfAQ9gYUJlTAOneZKt3YYpdNKuG6YpLVgBtUyMxpg4pS8OnrXFL9umEu_-Oxwnm3AumsvQEnQRjL4P8q6rtVCaFPRl3-hV3FLoS5ShVxyACFFpfiRcinmnHDq1_ofNt32wPq7cPtjuH0Nt_8Zbn-nfnGv3oYFx99PfqVZAXEEcr0Ke0x_Zv9D-wMk8bDz</recordid><startdate>20241201</startdate><enddate>20241201</enddate><creator>Sharma, Megha</creator><creator>Rahman, Faslu A. T.</creator><creator>Sharma, Gaurav</creator><creator>Dey, Sohini</creator><creator>Chellappa, Madhan Mohan</creator><creator>Sharma, Anshuk</creator><creator>Dhama, Kuldeep</creator><creator>Saikumar, G.</creator><creator>Kumar, Asok M.</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>20241201</creationdate><title>Immuno-pathogenesis study of local infectious bronchitis virus G1-1 lineage variant showed altered tissue tropism in experimental broiler chickens</title><author>Sharma, Megha ; Rahman, Faslu A. 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T.</creatorcontrib><creatorcontrib>Sharma, Gaurav</creatorcontrib><creatorcontrib>Dey, Sohini</creatorcontrib><creatorcontrib>Chellappa, Madhan Mohan</creatorcontrib><creatorcontrib>Sharma, Anshuk</creatorcontrib><creatorcontrib>Dhama, Kuldeep</creatorcontrib><creatorcontrib>Saikumar, G.</creatorcontrib><creatorcontrib>Kumar, Asok M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Veterinary research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sharma, Megha</au><au>Rahman, Faslu A. T.</au><au>Sharma, Gaurav</au><au>Dey, Sohini</au><au>Chellappa, Madhan Mohan</au><au>Sharma, Anshuk</au><au>Dhama, Kuldeep</au><au>Saikumar, G.</au><au>Kumar, Asok M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immuno-pathogenesis study of local infectious bronchitis virus G1-1 lineage variant showed altered tissue tropism in experimental broiler chickens</atitle><jtitle>Veterinary research communications</jtitle><stitle>Vet Res Commun</stitle><addtitle>Vet Res Commun</addtitle><date>2024-12-01</date><risdate>2024</risdate><volume>48</volume><issue>6</issue><spage>3683</spage><epage>3697</epage><pages>3683-3697</pages><issn>0165-7380</issn><issn>1573-7446</issn><eissn>1573-7446</eissn><abstract>Infectious bronchitis (IB) is an acute contagious disease of poultry caused by infectious bronchitis virus (IBV). This study investigated the immunopathogenesis and tissue tropism of an Indian IBV field isolate (IBV/Chicken/India/IVRI/Rajasthan/01/2023) in experimental broiler chickens. This isolate belongs to the G1-1 lineage and is closely associated with the Mass genotype. 10
6.23
EID
50
/0.2 mL of the virus was administered intranasally and intraocularly to the IBV-challenge group, whereas uninoculated allantoic fluid was administered to the control group. Clinical signs, gross and histopathological lesions, immunohistochemistry (IHC), viral load, humoral responses, and the relative expression of immune response genes were evaluated at seven observation points. The infected group showed a significant reduction in weight gain from 3 dpi onwards, with clinical signs of varying severity from 3 to − 11 dpi. Gross lesions and microscopic changes were observed in the nasal turbinates, trachea, lungs, and kidneys, mainly representing epithelial degeneration and necrosis with mononuclear infiltrates. The caecal tonsils also showed microscopic lesions at 7–9 dpi. Absolute viral load estimation in the organs corroborated the lesion severity scores and IHC results. The expression of innate immune responses broadly demonstrated higher expression in the trachea and lungs of the IBV-infected group during the early phase of infection, whereas similar responses were observed in the kidneys and caecal tonsils during the later phases of infection. This study suggests that the given IBV isolate may cause significant production losses in broilers and exhibit tissue tropism for both respiratory and non-respiratory tissues, triggering varying innate and adaptive immune responses.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>39222200</pmid><doi>10.1007/s11259-024-10525-7</doi><tpages>15</tpages></addata></record> |
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| subjects | Allantoic fluid Animals Biomedical and Life Sciences Bronchitis cecum chickens Chickens - virology Coronavirus Infections - immunology Coronavirus Infections - pathology Coronavirus Infections - veterinary Coronavirus Infections - virology epithelium genotype Genotypes histopathology immune response Immune response (humoral) Immunohistochemistry Immunopathogenesis India infectious bronchitis Infectious bronchitis virus Infectious bronchitis virus - genetics Infectious bronchitis virus - immunology Infectious bronchitis virus - pathogenicity Infectious bronchitis virus - physiology Innate immunity Kidneys Lesions Life Sciences Lungs necrosis Nose Poultry Poultry Diseases - immunology Poultry Diseases - pathology Poultry Diseases - virology tissue tropism Tonsil Trachea Tropism Veterinary Medicine/Veterinary Science viral load Viral Load - veterinary Viral Tropism Viruses weight gain Zoology |
| title | Immuno-pathogenesis study of local infectious bronchitis virus G1-1 lineage variant showed altered tissue tropism in experimental broiler chickens |
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