Skin-contact wearable electrochemical biosensing tools: A perspective for the wellbeing of neurological patients

• Published in: TrAC, Trends in analytical chemistry (Regular ed.) Trends in analytical chemistry (Regular ed.), 2024-11, Vol.180, p.117965, Article 117965
• Main Authors: Vitale, Ilaria Antonia, Fuochi, Neri, Martella, Daniele, Parmeggiani, Camilla, Marrazza, Giovanna, Palchetti, Ilaria
• Format: Article
• Language: English
• Subjects: analytical chemistry; biosensors; Electrochemical (bio)sensors; electrochemistry; health status; longevity; Microfluidic; Neurological disorders; people; Skin-contact devices; surveys; Sweat; Wearable
• ISSN: 0165-9936
• DOI: 10.1016/j.trac.2024.117965

Neurological Disorders (NDs) have become more prevalent with the increase of life expectancy. Wearable devices are particularly appealing for NDs since they would strongly facilitate the continuous health status monitoring in people that are not capable of communicating their needs or discomfort. This review summarizes the studies over the past five years reported in the literature regarding sampling and biosensing solutions for the development of wearable electroanalytical platforms. Our survey is mainly focused on skin-contact wearable biosensors, with a special emphasis on sweat sampling and analysis using biocompatible materials. Examples of devices for monitoring chemical parameters involved in the wellbeing of ND patients are discussed. [Display omitted] •Analytical approaches for analysis of sweat components related to neurological disorders are summarized.•Recent trends in electrochemical (bio)sensing accomplished within microfluidic chambers are reviewed.•A summary of the most common biocompatible materials used for skin-contact wearable sweat sampling devices is reported.•An overview of skin-contact wearable devices useful for monitoring the well-being of patients affected by neurological disorders.