Clostridioides difficile toxin B suppresses human neutrophil migration

We investigated the effects of Clostridioides difficile toxin B (TcdB), a major virulence factor in C. difficile infection (CDI), on human neutrophils. TcdB inhibits neutrophil migration via loss of polarity of F-actin polymerization in response to interleukin-8. TcdB facilitates CDI by allowing C....

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Bibliographic Details
Published in:Anaerobe 2024-12, Vol.90, p.102916, Article 102916
Main Authors: Kimura, Yoshitaka, Hatayama, Nami, Sato, Yoshinori, Yoshino, Yusuke
Format: Article
Language:English
Subjects:
actin
Actins - metabolism
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Bacterial Proteins - pharmacology
Bacterial Toxins - metabolism
Bacterial Toxins - toxicity
Cell Movement - drug effects
Clostridioides difficile - drug effects
Clostridium difficile
Humans
interleukin-8
Interleukin-8 - metabolism
neutrophils
Neutrophils - drug effects
Neutrophils - immunology
polymerization
toxins
virulence
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Summary:We investigated the effects of Clostridioides difficile toxin B (TcdB), a major virulence factor in C. difficile infection (CDI), on human neutrophils. TcdB inhibits neutrophil migration via loss of polarity of F-actin polymerization in response to interleukin-8. TcdB facilitates CDI by allowing C. difficile to avert the host immune system. •The effect of C. difficile toxin B (TcdB) on human neutrophils was investigated.•TcdB decreased the migration velocity and directionality of neutrophils.•TcdB disrupted the polarity of F-actin polymerization during migration.•TcdB allows C. difficile to evade the host immune system.
ISSN:1075-9964
1095-8274
1095-8274
DOI:10.1016/j.anaerobe.2024.102916