Protein-coding potential of non-canonical open reading frames in human transcriptome

In recent years, proteogenomics and ribosome profiling studies have identified a large number of proteins encoded by noncoding regions in the human genome. They are encoded by small open reading frames (sORFs) in the untranslated regions (UTRs) of mRNAs and long non-coding RNAs (lncRNAs). These sORF...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2023-12, Vol.684, p.149040-149040, Article 149040
Main Authors: Kore, Hitesh, Datta, Keshava K., Nagaraj, Shivashankar H., Gowda, Harsha
Format: Article
Language:English
Subjects:
DNA repair
embryogenesis
genome
humans
muscles
Non-coding RNAs
Novel proteins
Protein-coding potential
ribosomes
SEPs
transcriptome
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Summary:In recent years, proteogenomics and ribosome profiling studies have identified a large number of proteins encoded by noncoding regions in the human genome. They are encoded by small open reading frames (sORFs) in the untranslated regions (UTRs) of mRNAs and long non-coding RNAs (lncRNAs). These sORF encoded proteins (SEPs) are often
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2023.09.068