Integrated metabolomics and proteomics analysis to study the changes in Scutellaria baicalensis at different growth stages

[Display omitted] •Scutellaria baicalensis has two types: strip type (Ziqin) and rotten xylem (Kuqin)•The changes between Kuqin and Ziqin were analyzed by proteomics and metabolomics.•Metabolite transformation and protein expression from Ziqin to Kuqin were explained. Scutellaria baicalensis is a fu...

Full description

Saved in:
Bibliographic Details
Published in:Food chemistry 2023-09, Vol.419, p.136043-136043, Article 136043
Main Authors: Sun, Jiachen, Du, Lang, Qu, Zhuo, Wang, Huairui, Dong, Shengjie, Li, Xuejiao, Zhao, Hui
Format: Article
Language:English
Subjects:
Active ingredient
anthocyanins
biosynthesis
flavonols
food chemistry
functional foods
Growth year
harvest date
heat
large intestine
lungs
metabolites
Metabolome
Metabolomics
phenylalanine
protein synthesis
Proteome
Proteomics
Scutellaria baicalensis
Scutellaria baicalensis - growth & development
Scutellaria baicalensis - metabolism
tryptophan
tyrosine
xylem
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:[Display omitted] •Scutellaria baicalensis has two types: strip type (Ziqin) and rotten xylem (Kuqin)•The changes between Kuqin and Ziqin were analyzed by proteomics and metabolomics.•Metabolite transformation and protein expression from Ziqin to Kuqin were explained. Scutellaria baicalensis is a functional food that has the potential to treat various diseases. Scutellaria baicalensis can be divided into two types: Ziqin (strip types) and (rotten xylem). Ziqin is used to clear lower energizer large intestine heat syndrome, while Kuqin is used for the treatment of upper energizer lung heat syndrome. At present, the substance basis of the differences between Ziqin and Kuqin is not clear. The changes in metabolite accumulation and protein expression between them were analyzed by the non-targeted metabolomic technique in combination with the label-free proteomics approach. The results showed that the differentially accumulated metabolites and abundant proteins were mainly enriched in the pathways of phenylalanine, tyrosine and tryptophan biosynthesis, phenylpropanoid biosynthesis, flavonoid biosynthesis, flavone and flavonol biosynthesis, isoflavonoid biosynthesis, and anthocyanin biosynthesis. Collectively, these results reveal the changes of Scutellaria baicalensis in different growth years and provide a reference for selecting the appropriate harvest period.
ISSN:0308-8146
1873-7072
DOI:10.1016/j.foodchem.2023.136043