Loading…
Combination of closing-wedge distal femoral osteotomy and modified tibial plateau levelling osteotomy for the treatment of medial patellar luxation and concomitant cranial cruciate ligament disease in dogs
Considering the prevalence of cranial cruciate ligament disease (CCLD) and concurrent medial patellar luxation (MPL) among dogs, and the concomitant bone deviations routinely identified, the aim of this study is to evaluate the efficacy of the combination between distal femoral osteotomy (DFO) and m...
Saved in:
Published in: | Research in veterinary science 2024-11, Vol.180, p.105437, Article 105437 |
---|---|
Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | |
---|---|
cites | cdi_FETCH-LOGICAL-c270t-99353098b297a5758e56db16d80f580eebd023a11c0cf85328bdf118acee217c3 |
container_end_page | |
container_issue | |
container_start_page | 105437 |
container_title | Research in veterinary science |
container_volume | 180 |
creator | Costa Junior, Jose Sergio Curuci, Eloy Henrique Pares Carneiro, Rafael Kretzer Nobile, Matheus Giufrida, Rogério Dias, Luís Gustavo Gosuen Gonçalves Carrera, Alefe Luiz Caliani Minto, Bruno Watanabe |
description | Considering the prevalence of cranial cruciate ligament disease (CCLD) and concurrent medial patellar luxation (MPL) among dogs, and the concomitant bone deviations routinely identified, the aim of this study is to evaluate the efficacy of the combination between distal femoral osteotomy (DFO) and modified tibial plateau levelling osteotomy (mTPLO) for the treatment of MPL with distal femoral varus, tibial torsion, and CCLD. Dogs with concurrent MPL and CCLD that underwent DFO and mTPLO procedures were included. Subjective clinical evaluations of gait and pre-operative and immediate post-operative radiographic examinations were performed. Surgical data were documented. The anatomical lateral distal femoral angle (aLDFA), femoral varus angle, mechanical medial proximal tibial angle, and tibial plateau angle (TPA) were compared between the pre- and post-operative periods. A total of 12 dogs were included in this study. Closing-wedge DFO and mTPLO procedures were performed on 14 limbs. The mean pre-operative and post-operative aLDFA values were 104.8 ± 3.9° and 95.4 ± 2.4°, respectively. TPA values were 26.2 ± 3.7° pre-operatively and 6.3 ± 3.2° post-operatively. Bone healing was observed in 7.1 %, 71.3 %, and 85.5 % of patients at the first, second, and third follow-up, respectively. Lameness was resolved in 28.5 %, 78.5 %, and 100 % at 30, 60, and 90 days, respectively. No major peri- or post-operative complications were reported. The combination of mTPLO and DFO aligns the stifle extensor mechanism, promoting dynamic stabilization. It can be considered for the treatment of concurrent MPL and CCLD in dogs, performed as a single procedure, and is associated with favorable short-term outcomes.
•Study evaluates combination of DFO and mTPLO for treating MPL and CCLD in dogs.•12 dogs with MPL and CCLD underwent DFO and mTPLO on 14 limbs.•Significant improvement in anatomical angles and lameness resolution observed.•Bone healing noted in 85.5 % of patients by third follow-up.•Combination procedure aligns stifle extensor mechanism with no complications. |
doi_str_mv | 10.1016/j.rvsc.2024.105437 |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3154187825</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0034528824003047</els_id><sourcerecordid>3118834452</sourcerecordid><originalsourceid>FETCH-LOGICAL-c270t-99353098b297a5758e56db16d80f580eebd023a11c0cf85328bdf118acee217c3</originalsourceid><addsrcrecordid>eNqNkc2OFCEUhYnROO3oC7gwLN1Uy09RRSVuTMe_ZBI3uiYU3GrpUNAC1ToP6TtJTY3GlXF1E_jO4XIOQs8p2VNCu1enfbpks2eEtfVAtLx_gHZUcNawrqMP0Y4Q3jaCSXmFnuR8IoS0lPaP0RUfWta3fbdDPw9xHl3QxcWA44SNj9mFY_Md7BGwdblojyeYY6oz5gKxxPkW62DxHK2bHFhc3Ojq7dnrAnrBHi7gfTX5i59iwuUr4JJAlxlCWd-awd7pqsx7nbBffmx7rO4mBhNnV3RlTdJhJU1ajKs09u6o71zqgqAzYBewjcf8FD2atM_w7H5eoy_v3n4-fGhuPr3_eHhz0xjWk9IMAxecDHJkQ69FLySIzo60s5JMQhKA0RLGNaWGmEnWQOVoJ0qlNgCM9oZfo5eb7znFbwvkomaXzfqLAHHJilPRUtlLJv4DpVLythWsomxDTYo5J5jUOblZp1tFiVobVye1Nq7WxtXWeBW9uPdfxhroH8nviivwegOgBnJxkFQ2DoKp4ScwRdno_uX_CwjBwmA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3118834452</pqid></control><display><type>article</type><title>Combination of closing-wedge distal femoral osteotomy and modified tibial plateau levelling osteotomy for the treatment of medial patellar luxation and concomitant cranial cruciate ligament disease in dogs</title><source>Elsevier</source><creator>Costa Junior, Jose Sergio ; Curuci, Eloy Henrique Pares ; Carneiro, Rafael Kretzer ; Nobile, Matheus ; Giufrida, Rogério ; Dias, Luís Gustavo Gosuen Gonçalves ; Carrera, Alefe Luiz Caliani ; Minto, Bruno Watanabe</creator><creatorcontrib>Costa Junior, Jose Sergio ; Curuci, Eloy Henrique Pares ; Carneiro, Rafael Kretzer ; Nobile, Matheus ; Giufrida, Rogério ; Dias, Luís Gustavo Gosuen Gonçalves ; Carrera, Alefe Luiz Caliani ; Minto, Bruno Watanabe</creatorcontrib><description>Considering the prevalence of cranial cruciate ligament disease (CCLD) and concurrent medial patellar luxation (MPL) among dogs, and the concomitant bone deviations routinely identified, the aim of this study is to evaluate the efficacy of the combination between distal femoral osteotomy (DFO) and modified tibial plateau levelling osteotomy (mTPLO) for the treatment of MPL with distal femoral varus, tibial torsion, and CCLD. Dogs with concurrent MPL and CCLD that underwent DFO and mTPLO procedures were included. Subjective clinical evaluations of gait and pre-operative and immediate post-operative radiographic examinations were performed. Surgical data were documented. The anatomical lateral distal femoral angle (aLDFA), femoral varus angle, mechanical medial proximal tibial angle, and tibial plateau angle (TPA) were compared between the pre- and post-operative periods. A total of 12 dogs were included in this study. Closing-wedge DFO and mTPLO procedures were performed on 14 limbs. The mean pre-operative and post-operative aLDFA values were 104.8 ± 3.9° and 95.4 ± 2.4°, respectively. TPA values were 26.2 ± 3.7° pre-operatively and 6.3 ± 3.2° post-operatively. Bone healing was observed in 7.1 %, 71.3 %, and 85.5 % of patients at the first, second, and third follow-up, respectively. Lameness was resolved in 28.5 %, 78.5 %, and 100 % at 30, 60, and 90 days, respectively. No major peri- or post-operative complications were reported. The combination of mTPLO and DFO aligns the stifle extensor mechanism, promoting dynamic stabilization. It can be considered for the treatment of concurrent MPL and CCLD in dogs, performed as a single procedure, and is associated with favorable short-term outcomes.
•Study evaluates combination of DFO and mTPLO for treating MPL and CCLD in dogs.•12 dogs with MPL and CCLD underwent DFO and mTPLO on 14 limbs.•Significant improvement in anatomical angles and lameness resolution observed.•Bone healing noted in 85.5 % of patients by third follow-up.•Combination procedure aligns stifle extensor mechanism with no complications.</description><identifier>ISSN: 0034-5288</identifier><identifier>ISSN: 1532-2661</identifier><identifier>EISSN: 1532-2661</identifier><identifier>DOI: 10.1016/j.rvsc.2024.105437</identifier><identifier>PMID: 39427476</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Anterior Cruciate Ligament - surgery ; Anterior Cruciate Ligament Injuries - surgery ; Anterior Cruciate Ligament Injuries - veterinary ; cranial cruciate ligament ; Dog ; Dog Diseases - surgery ; Dogs ; Female ; Femoral varus ; Femur - surgery ; gait ; lameness ; Male ; Osteotomy ; Osteotomy - methods ; Osteotomy - veterinary ; Patellar Dislocation - surgery ; Patellar Dislocation - veterinary ; radiography ; Stifle ; Stifle - surgery ; tibia ; Tibia - surgery ; veterinary medicine</subject><ispartof>Research in veterinary science, 2024-11, Vol.180, p.105437, Article 105437</ispartof><rights>2024 Elsevier Ltd</rights><rights>Copyright © 2024 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c270t-99353098b297a5758e56db16d80f580eebd023a11c0cf85328bdf118acee217c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39427476$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Costa Junior, Jose Sergio</creatorcontrib><creatorcontrib>Curuci, Eloy Henrique Pares</creatorcontrib><creatorcontrib>Carneiro, Rafael Kretzer</creatorcontrib><creatorcontrib>Nobile, Matheus</creatorcontrib><creatorcontrib>Giufrida, Rogério</creatorcontrib><creatorcontrib>Dias, Luís Gustavo Gosuen Gonçalves</creatorcontrib><creatorcontrib>Carrera, Alefe Luiz Caliani</creatorcontrib><creatorcontrib>Minto, Bruno Watanabe</creatorcontrib><title>Combination of closing-wedge distal femoral osteotomy and modified tibial plateau levelling osteotomy for the treatment of medial patellar luxation and concomitant cranial cruciate ligament disease in dogs</title><title>Research in veterinary science</title><addtitle>Res Vet Sci</addtitle><description>Considering the prevalence of cranial cruciate ligament disease (CCLD) and concurrent medial patellar luxation (MPL) among dogs, and the concomitant bone deviations routinely identified, the aim of this study is to evaluate the efficacy of the combination between distal femoral osteotomy (DFO) and modified tibial plateau levelling osteotomy (mTPLO) for the treatment of MPL with distal femoral varus, tibial torsion, and CCLD. Dogs with concurrent MPL and CCLD that underwent DFO and mTPLO procedures were included. Subjective clinical evaluations of gait and pre-operative and immediate post-operative radiographic examinations were performed. Surgical data were documented. The anatomical lateral distal femoral angle (aLDFA), femoral varus angle, mechanical medial proximal tibial angle, and tibial plateau angle (TPA) were compared between the pre- and post-operative periods. A total of 12 dogs were included in this study. Closing-wedge DFO and mTPLO procedures were performed on 14 limbs. The mean pre-operative and post-operative aLDFA values were 104.8 ± 3.9° and 95.4 ± 2.4°, respectively. TPA values were 26.2 ± 3.7° pre-operatively and 6.3 ± 3.2° post-operatively. Bone healing was observed in 7.1 %, 71.3 %, and 85.5 % of patients at the first, second, and third follow-up, respectively. Lameness was resolved in 28.5 %, 78.5 %, and 100 % at 30, 60, and 90 days, respectively. No major peri- or post-operative complications were reported. The combination of mTPLO and DFO aligns the stifle extensor mechanism, promoting dynamic stabilization. It can be considered for the treatment of concurrent MPL and CCLD in dogs, performed as a single procedure, and is associated with favorable short-term outcomes.
•Study evaluates combination of DFO and mTPLO for treating MPL and CCLD in dogs.•12 dogs with MPL and CCLD underwent DFO and mTPLO on 14 limbs.•Significant improvement in anatomical angles and lameness resolution observed.•Bone healing noted in 85.5 % of patients by third follow-up.•Combination procedure aligns stifle extensor mechanism with no complications.</description><subject>Animals</subject><subject>Anterior Cruciate Ligament - surgery</subject><subject>Anterior Cruciate Ligament Injuries - surgery</subject><subject>Anterior Cruciate Ligament Injuries - veterinary</subject><subject>cranial cruciate ligament</subject><subject>Dog</subject><subject>Dog Diseases - surgery</subject><subject>Dogs</subject><subject>Female</subject><subject>Femoral varus</subject><subject>Femur - surgery</subject><subject>gait</subject><subject>lameness</subject><subject>Male</subject><subject>Osteotomy</subject><subject>Osteotomy - methods</subject><subject>Osteotomy - veterinary</subject><subject>Patellar Dislocation - surgery</subject><subject>Patellar Dislocation - veterinary</subject><subject>radiography</subject><subject>Stifle</subject><subject>Stifle - surgery</subject><subject>tibia</subject><subject>Tibia - surgery</subject><subject>veterinary medicine</subject><issn>0034-5288</issn><issn>1532-2661</issn><issn>1532-2661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqNkc2OFCEUhYnROO3oC7gwLN1Uy09RRSVuTMe_ZBI3uiYU3GrpUNAC1ToP6TtJTY3GlXF1E_jO4XIOQs8p2VNCu1enfbpks2eEtfVAtLx_gHZUcNawrqMP0Y4Q3jaCSXmFnuR8IoS0lPaP0RUfWta3fbdDPw9xHl3QxcWA44SNj9mFY_Md7BGwdblojyeYY6oz5gKxxPkW62DxHK2bHFhc3Ojq7dnrAnrBHi7gfTX5i59iwuUr4JJAlxlCWd-awd7pqsx7nbBffmx7rO4mBhNnV3RlTdJhJU1ajKs09u6o71zqgqAzYBewjcf8FD2atM_w7H5eoy_v3n4-fGhuPr3_eHhz0xjWk9IMAxecDHJkQ69FLySIzo60s5JMQhKA0RLGNaWGmEnWQOVoJ0qlNgCM9oZfo5eb7znFbwvkomaXzfqLAHHJilPRUtlLJv4DpVLythWsomxDTYo5J5jUOblZp1tFiVobVye1Nq7WxtXWeBW9uPdfxhroH8nviivwegOgBnJxkFQ2DoKp4ScwRdno_uX_CwjBwmA</recordid><startdate>202411</startdate><enddate>202411</enddate><creator>Costa Junior, Jose Sergio</creator><creator>Curuci, Eloy Henrique Pares</creator><creator>Carneiro, Rafael Kretzer</creator><creator>Nobile, Matheus</creator><creator>Giufrida, Rogério</creator><creator>Dias, Luís Gustavo Gosuen Gonçalves</creator><creator>Carrera, Alefe Luiz Caliani</creator><creator>Minto, Bruno Watanabe</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>202411</creationdate><title>Combination of closing-wedge distal femoral osteotomy and modified tibial plateau levelling osteotomy for the treatment of medial patellar luxation and concomitant cranial cruciate ligament disease in dogs</title><author>Costa Junior, Jose Sergio ; Curuci, Eloy Henrique Pares ; Carneiro, Rafael Kretzer ; Nobile, Matheus ; Giufrida, Rogério ; Dias, Luís Gustavo Gosuen Gonçalves ; Carrera, Alefe Luiz Caliani ; Minto, Bruno Watanabe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c270t-99353098b297a5758e56db16d80f580eebd023a11c0cf85328bdf118acee217c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Anterior Cruciate Ligament - surgery</topic><topic>Anterior Cruciate Ligament Injuries - surgery</topic><topic>Anterior Cruciate Ligament Injuries - veterinary</topic><topic>cranial cruciate ligament</topic><topic>Dog</topic><topic>Dog Diseases - surgery</topic><topic>Dogs</topic><topic>Female</topic><topic>Femoral varus</topic><topic>Femur - surgery</topic><topic>gait</topic><topic>lameness</topic><topic>Male</topic><topic>Osteotomy</topic><topic>Osteotomy - methods</topic><topic>Osteotomy - veterinary</topic><topic>Patellar Dislocation - surgery</topic><topic>Patellar Dislocation - veterinary</topic><topic>radiography</topic><topic>Stifle</topic><topic>Stifle - surgery</topic><topic>tibia</topic><topic>Tibia - surgery</topic><topic>veterinary medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Costa Junior, Jose Sergio</creatorcontrib><creatorcontrib>Curuci, Eloy Henrique Pares</creatorcontrib><creatorcontrib>Carneiro, Rafael Kretzer</creatorcontrib><creatorcontrib>Nobile, Matheus</creatorcontrib><creatorcontrib>Giufrida, Rogério</creatorcontrib><creatorcontrib>Dias, Luís Gustavo Gosuen Gonçalves</creatorcontrib><creatorcontrib>Carrera, Alefe Luiz Caliani</creatorcontrib><creatorcontrib>Minto, Bruno Watanabe</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Research in veterinary science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Costa Junior, Jose Sergio</au><au>Curuci, Eloy Henrique Pares</au><au>Carneiro, Rafael Kretzer</au><au>Nobile, Matheus</au><au>Giufrida, Rogério</au><au>Dias, Luís Gustavo Gosuen Gonçalves</au><au>Carrera, Alefe Luiz Caliani</au><au>Minto, Bruno Watanabe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combination of closing-wedge distal femoral osteotomy and modified tibial plateau levelling osteotomy for the treatment of medial patellar luxation and concomitant cranial cruciate ligament disease in dogs</atitle><jtitle>Research in veterinary science</jtitle><addtitle>Res Vet Sci</addtitle><date>2024-11</date><risdate>2024</risdate><volume>180</volume><spage>105437</spage><pages>105437-</pages><artnum>105437</artnum><issn>0034-5288</issn><issn>1532-2661</issn><eissn>1532-2661</eissn><abstract>Considering the prevalence of cranial cruciate ligament disease (CCLD) and concurrent medial patellar luxation (MPL) among dogs, and the concomitant bone deviations routinely identified, the aim of this study is to evaluate the efficacy of the combination between distal femoral osteotomy (DFO) and modified tibial plateau levelling osteotomy (mTPLO) for the treatment of MPL with distal femoral varus, tibial torsion, and CCLD. Dogs with concurrent MPL and CCLD that underwent DFO and mTPLO procedures were included. Subjective clinical evaluations of gait and pre-operative and immediate post-operative radiographic examinations were performed. Surgical data were documented. The anatomical lateral distal femoral angle (aLDFA), femoral varus angle, mechanical medial proximal tibial angle, and tibial plateau angle (TPA) were compared between the pre- and post-operative periods. A total of 12 dogs were included in this study. Closing-wedge DFO and mTPLO procedures were performed on 14 limbs. The mean pre-operative and post-operative aLDFA values were 104.8 ± 3.9° and 95.4 ± 2.4°, respectively. TPA values were 26.2 ± 3.7° pre-operatively and 6.3 ± 3.2° post-operatively. Bone healing was observed in 7.1 %, 71.3 %, and 85.5 % of patients at the first, second, and third follow-up, respectively. Lameness was resolved in 28.5 %, 78.5 %, and 100 % at 30, 60, and 90 days, respectively. No major peri- or post-operative complications were reported. The combination of mTPLO and DFO aligns the stifle extensor mechanism, promoting dynamic stabilization. It can be considered for the treatment of concurrent MPL and CCLD in dogs, performed as a single procedure, and is associated with favorable short-term outcomes.
•Study evaluates combination of DFO and mTPLO for treating MPL and CCLD in dogs.•12 dogs with MPL and CCLD underwent DFO and mTPLO on 14 limbs.•Significant improvement in anatomical angles and lameness resolution observed.•Bone healing noted in 85.5 % of patients by third follow-up.•Combination procedure aligns stifle extensor mechanism with no complications.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>39427476</pmid><doi>10.1016/j.rvsc.2024.105437</doi></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0034-5288 |
ispartof | Research in veterinary science, 2024-11, Vol.180, p.105437, Article 105437 |
issn | 0034-5288 1532-2661 1532-2661 |
language | eng |
recordid | cdi_proquest_miscellaneous_3154187825 |
source | Elsevier |
subjects | Animals Anterior Cruciate Ligament - surgery Anterior Cruciate Ligament Injuries - surgery Anterior Cruciate Ligament Injuries - veterinary cranial cruciate ligament Dog Dog Diseases - surgery Dogs Female Femoral varus Femur - surgery gait lameness Male Osteotomy Osteotomy - methods Osteotomy - veterinary Patellar Dislocation - surgery Patellar Dislocation - veterinary radiography Stifle Stifle - surgery tibia Tibia - surgery veterinary medicine |
title | Combination of closing-wedge distal femoral osteotomy and modified tibial plateau levelling osteotomy for the treatment of medial patellar luxation and concomitant cranial cruciate ligament disease in dogs |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T12%3A57%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Combination%20of%20closing-wedge%20distal%20femoral%20osteotomy%20and%20modified%20tibial%20plateau%20levelling%20osteotomy%20for%20the%20treatment%20of%20medial%20patellar%20luxation%20and%20concomitant%20cranial%20cruciate%20ligament%20disease%20in%20dogs&rft.jtitle=Research%20in%20veterinary%20science&rft.au=Costa%20Junior,%20Jose%20Sergio&rft.date=2024-11&rft.volume=180&rft.spage=105437&rft.pages=105437-&rft.artnum=105437&rft.issn=0034-5288&rft.eissn=1532-2661&rft_id=info:doi/10.1016/j.rvsc.2024.105437&rft_dat=%3Cproquest_cross%3E3118834452%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c270t-99353098b297a5758e56db16d80f580eebd023a11c0cf85328bdf118acee217c3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3118834452&rft_id=info:pmid/39427476&rfr_iscdi=true |