Bacterial acid stress response: from cellular changes to antibiotic tolerance and phenotypic heterogeneity

Most bacteria are neutralophiles but can survive fluctuations in pH in their environment. Herein, we provide an overview of the adaptation of several human, soil and food bacteria to acid stress, mainly based on next generation sequencing studies, highlighting common and specific strategies. We also...

Full description

Saved in:
Bibliographic Details
Published in:Current opinion in microbiology 2023-10, Vol.75, p.102367-102367, Article 102367
Main Authors: Schumacher, Kilian, Brameyer, Sophie, Jung, Kirsten
Format: Article
Language:English
Subjects:
antibiotic resistance
humans
microbiology
phenotypic variation
soil
stress response
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Most bacteria are neutralophiles but can survive fluctuations in pH in their environment. Herein, we provide an overview of the adaptation of several human, soil and food bacteria to acid stress, mainly based on next generation sequencing studies, highlighting common and specific strategies. We also discuss the interplay between acid stress response and antibiotic tolerance, as well as the response of individual cells. •Bacteria have common and species-specific mechanisms to survive acid stress•Acid stress response and antibiotic tolerance are interconnected•Acid stress response is heterogeneous
ISSN:1369-5274
1879-0364
DOI:10.1016/j.mib.2023.102367